ヒト胎児前庭神経核の形態計測学的検討方法について

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  • Morphometric Evaluation of the Human Fetal Vestibular Nuclei.

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Morphometric observation and evaluation consisting of celloidine serial sections, a microscope with a drawing tube, an image analyser and a computer are necessary for the precise understanding of the morphological development of the human nervous system with great objectivity. We introduced this method and particular anatomic parameters such as the circularity ratio (CR) and neuropil index (NI) with the preliminary data of the vestibular nuclei at 40 weeks of gestation (WG). For the analysis of the maturity of neurons, CR of neuronal somata, 47πA/L2 (A=area in um2; L=perimeter in pm), was calculated. The CR of a regular circle is 1.0. We evaluated the maturation of the neuropil defined as the tissue around each neuron including the axons, dendrites, myelin sheaths, glial cell bodies and their processes, vessels and connective tissue. The NI was calculated as follows: NI=[(total columnar area in mm)-(total neuronal area in mm)] X 103/neuronal number; We measured sections to obtain several morphometric parameters: the volume of the nuclear column, and number, packing density and cell body area of neurons, and calculated CR and NI, demonstrating the value at 40 WG. We are currently preparing to examine the development of the human lateral vestibular nucleus in 14 fetuses (6-40 WG), an infant (2 months old) and an adult (63 years old).

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