メニエール病に対する薬物治療の短期および長期評価 : 自然経過を考慮した検討  [in Japanese] Evaluation of Effects of Treatment on Meniere's Disease on the Basis of Natural Course  [in Japanese]

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Abstract

To evaluate short and long term effect of treatment on Meniere's disease, the clinical course was examined in 25 patients treated with Isosorbide compared with the natural course without any treatment in 20 patients. Vertigo, hearing level, tinnitus and disability were assessed 4 and 8 week and 1 year after the start of clinical observation for patients respectively using the number of vertigo spells, 4-frequency pure tone average at 250, 500, 1000 and 2000 Hz, 5-staged score and 4-staged score based on the guidelines of Japan society for equilibrium reseach in Meniere's disease. Vertigo and disability in the treated group improved more significantly (P<0.05) than that in the group allowed to follow the natural course without significant change in either hearing level or tinnitus 4 week after starting observation. In contrast, there is no significant differences in the improvement of all four symptoms between the natural and treated groups 8 week and 1 year following starting observation. The effect of the drug was markedly demonstrated in the initial stage of disease. Evaluation of the short and long term effect of treatment on Meniere's disease should be performed on the basis of natural course which requires further examination to establish.

Journal

  • Equilibrium Research

    Equilibrium Research 56(6), 594-600, 1997-12-01

    Japan Society for Equilibrium Research

References:  17

Cited by:  9

Codes

  • NII Article ID (NAID)
    10008710091
  • NII NACSIS-CAT ID (NCID)
    AN00001485
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03855716
  • Data Source
    CJP  CJPref  J-STAGE 
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