初期に神経耳科学的検討を行い得たCreutzfeldt-Jakob病の一例 Neuro-Otological Evaluation in the Early Stage of Creutzfeldt-Jakob Disease
A fifty-year-old woman began to complain of a dizzy sensation in March 1996. Thereafter, she became unable to do her house-work and often remained in bed. She first consulted our hospital in May. On the initial examination, she showed gaze nystagmus on rightward, leftward and upward gaze. At that time, electronystagmographic test showed abnormal pursuit ocular movement and optokinetic nystagmus was hardly provoked, although saccadic ocular movement appeared normal. She was soon admitted to our hospital. Two weeks later, a second electronystagmographic test recording was taken, demonstrating disappearance of optokinetic nystagmus provocation as well as visual suppression on caloric test. Stabilometer test showed remarkable regressive changes during these two weeks.<BR>Auditory brainstem response was normal at that time, even though electroencephalography typically showed a periodic synchronous discharge. We found that the patient had been taking some powdered bovine bone products daily for more than ten years.<BR>From these data, we diagnosed Creutzfeldt-Jakob disease. Thereafter, she became akinetic and mute and in July 1996 often took a decorticated posture, associated with periodic alternating gaze deviation.
- Equilibrium research
Equilibrium research 57(3), 316-321, 1998-06-01