第7補体欠損症に合併した髄膜炎菌感染症  [in Japanese] Meningococcemia Associated with C7 Deficiency  [in Japanese]

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Author(s)

    • 尾藤 誠司 BITO Seiji
    • 国立病院東京医療センター総合診療科 National Tokyo Medical Center Dept. of General Internal Medicine
    • 新保 卓郎 SHINBO Takuro
    • 京都大学附属病院総合診療部 Kyoto University Hospital Dept. of General Medicine and Clinical Epidemiology
    • 伊藤 澄信 ITO Suminobu
    • 国立病院東京医療センター総合診療科 National Tokyo Medical Center Dept. of General Internal Medicine
    • 青木 誠 AOKI Makoto
    • 国立病院東京医療センター総合診療科 National Tokyo Medical Center Dept. of General Internal Medicine

Abstract

We report a 20-year-old woman who developed meningococcemia. The patient developed fever, vomiting and skin rash, then was sent to our hospital for shock. Physical and laboratory examination revealed septic shock and DIC. Her blood culture grew Neisseria meningitidis (W135). She recovered promptly with PCG, gabexate mesilate and intensive care for shock.<BR>Hemolytic activities of the patient's complement were less than 12/CHSO during the course. Screening for each component of the complements suggested that this patient had deficiency of C7.<BR>Meningococcal disease has seldom seen in Japan. Early recognition is essential so that appropriate antibiotic therapy and supportive care can be promptly started because shock and death may ensure within hours after onset of symptoms.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 74(9), 720-723, 2000-09-20

    The Japanese Association for Infectious Diseases

References:  6

Cited by:  3

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