化膿性髄膜炎患児の髄液中抗インターロイキン8 IgG 自己抗体の経時的測定  [in Japanese] Serial Measurement of Anti-interleukin-8 IgG Autoantibody in Cerebrospinal Fluid of Infants with Bacterial Meningitis  [in Japanese]

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Author(s)

Abstract

化膿性髄膜炎の髄液中インターロイキン8 (IL-8) 及び抗IL-8IgG自己抗体を経時的に測定し, 髄膜炎の否定された児から入院時に得られた髄液中のその値と比較した. 化膿性髄膜炎患児の治療開始前の髄液中には多量のIL-8が含まれているが, その濃度は治療開始に伴い急速に低下する. このため, 化膿性髄膜炎患児の髄液中IL-8濃度が髄膜炎の否定された児の髄液中IL-8濃度に比して有意に高値をとるのは治療開始前のみであった. しかし, 抗IL-8IgG自己抗体の濃度低下はこれに遅れ, 治療開始後15日まで髄膜炎の否定された児のその値に比して有意に高値であった. 髄液中IL-8値が正常に復した後であっても, 抗IL-8IgG自己抗体を測定することによって髄液中に多量のIL-8が存在したことを示すことができる可能性がある.

We serially measured concentrations of interleukin (IL)-8 and anti-IL-8 IgG autoantibody in cerebrospinal fluid of infants with bacterial meningitis, and also measured these concentrations in cerebrospinal fluid obtained from infants without meningitis on admission. We have reported that the IL-8 concentration in cerebrospinal fluid of infants with purulent meningitis rapidly decreases after the initiation of therapy. Thus, in the present study, the IL-8 concentration in infants with purulent meningitis only before the initiation of therapy was significantly higher compared with that in infants without meningitis. However, the concentration of anti-IL-8 IgG autoantibody was still high after the initiation of therapy. The concentration of anti-IL-8 IgG autoantibody was significantly higher compared with that in infants without meningitis until the 15th day after the initiation of therapy. The time lag between the decrease of IL-8 and anti-IL-8 IgG autoantibody demonstrated in the present study could be used to indicate the past presence of a large amount of IL-8, even if the IL-8 concentration was already low

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 74(10), 811-815, 2000-10-20

    The Japanese Association for Infectious Diseases

References:  11

Codes

  • NII Article ID (NAID)
    10008713523
  • NII NACSIS-CAT ID (NCID)
    AN00047715
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    03875911
  • NDL Article ID
    5530738
  • NDL Source Classification
    ZS9(科学技術--医学--病理学・微生物学・寄生虫学・感染・免疫学・血清学・アレルギー)
  • NDL Call No.
    Z19-193
  • Data Source
    CJP  NDL  J-STAGE 
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