Anti-LPS Antibodies in Adult and Infant Patients Infected with Enterohemorrhagic <I>Escherichia coli</I> O157

• ADACHI Eriko

  Department of Infectious Diseases Research, National Children's Medical Research Center

• YOSHINO Ken-ichi

  Department of Infectious Diseases Research, National Children's Medical Research Center

• TAKEDA Tae

  Department of Infectious Diseases Research, National Children's Medical Research Center

Bibliographic Information

Other Title

• 腸管出血性大腸菌O157の成人, 小児患者および成人保菌者の抗O157 LPS抗体価の変動
• チョウカン シュッケツセイ ダイチョウキン O157 ノ セイジン ショウニ カンジャ オヨビ セイジン ホキンシャ ノ コウO157 LPS コウタイカ ノ ヘンドウ
• Anti-LPS Antibodies in Adult and Infant Patients Infected with Enterohemorrhagic Escherichia coli O157

Abstract

The antibodies against LPS of enterohemorrhagic Escherichia coli (EHEC) O157 in sera from patients infected with this organism and sera from healthy control subjects were examined by ELISA to investigate their immune response. Analysing these data, we found some heterogeneity of antibody response between adults and infants.<BR>In healthy adults and children, the cutoff values for IgM antibodies to O157 LPS were calculated as 0.85, 0.40 and for IgG were as 0.57, 0.39 respectively. In patients, the ELISA values of adult were lower and decreased earlier than those of children. Therefore sero diagnosis for EHEC O157 infection for adult patients the timing of blood collection is very important. On the other hand, in some patients the sera of children showed a high level of IgM only 3 days from the onset. This tendency seemed to be related to severity of the disease. This immunological test was proved to be useless for healthy carriers because the antibodies against O157 LPS were not observed in their sera.

Journal

• Kansenshogaku Zasshi

  Kansenshogaku Zasshi 73 (8), 772-777, 1999

  The Japanese Association for Infectious Diseases

Keywords

• <I>Escherichia coli</I> O157
• anti-LPS antibody
• ELISA

Details

• CRID: 1390282680025759872
• NII Article ID: 130004330801
• NII Article ID: 10008716309
• NII Book ID: AN00047715
• DOI: 10.11150/kansenshogakuzasshi1970.73.772
• COI: 1:STN:280:DyaK1Mvhs1Cqsw%3D%3D
• ISSN: 1884569X
• ISSN: 03875911
• NDL BIB ID: 4834488
• PubMed: 10487023
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4834488
• Web Site: https://search.jamas.or.jp/link/ui/2000057689
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed