<I>In Vitro</I> Drug Susceptibility Test of <I>Plasmodium falciparum</I> Using a Portable Thermostat and CO<SUB>2</SUB> Gas Generator

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  • LIN Qinghua
    Department of Parasitology, Gunma University School of Medicine
  • ONDA Tomoko
    Department of Parasitology, Gunma University School of Medicine
  • KANO Shigeyuki
    Department of Appropriate Technology Development and Transfer, Research Institute, International Medical Center of Japan
  • MASUDA Gohta
    Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital
  • SUZUKI Mamoru
    Department of Parasitology, Gunma University School of Medicine

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Other Title
  • 酸素吸収・炭酸ガス発生剤とポータブル小型恒温槽を用いた熱帯熱マラリア原虫の薬剤感受性試験
  • サンソ キュウシュウ タンサン ガス ハッセイザイ ト ポータブル コガタ コウオンソウ オ モチイタ ネッタイ ネツ マラリア ゲンチュウ ノ ヤクザイ カンジュセイ シケン
  • In Vitro Drug Susceptibility Test of Plasmodium falciparum Using a Portable Thermostat and CO2 Gas Generator

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Abstract

We have recently developed a method of in vitro cultivation of P. falciparum using a portable incubator and Anaero Pack®·CO2 (Onda et al.), we applied semi-microtechnique drug susceptibility tests to the culture method to evaluate the system using several P. falciparum strains or isolates of different susceptibilities to chloroquine (SGE-1, FCR-3, K-1, Patient 1 and 2). The new method gave comparable results to those shown by the standard test employing a modular incubator chamber with standard gas composition of 5%O2, 5%CO2 and 90%N2. Many useful data on the epidemiology of drug resistant malaria such as the emergence of multi-drug resistant isolates could be collected by applying this new method to the field survey.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 73 (11), 1099-1103, 1999

    The Japanese Association for Infectious Diseases

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