Increased IL-2 and sIL-2R in Sera of Infants with HTLV-I Infection from Mother

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  • MORI Kohji
    Department of Microbiology, The Tokyo Metropolitan Research Laboratory of Public Health
  • SADAMASU Kenji
    Department of Microbiology, The Tokyo Metropolitan Research Laboratory of Public Health
  • TABEI Yukiko
    Department of Microbiology, The Tokyo Metropolitan Research Laboratory of Public Health
  • MONMA Kimio
    Department of Microbiology, The Tokyo Metropolitan Research Laboratory of Public Health
  • HIRATA Ichiro
    Department of Microbiology, The Tokyo Metropolitan Research Laboratory of Public Health
  • SEKINE Hiromasa
    Department of Microbiology, The Tokyo Metropolitan Research Laboratory of Public Health
  • ITOH Takeshi
    Department of Microbiology, The Tokyo Metropolitan Research Laboratory of Public Health
  • WATANABE Tohru
    The Tokyo Metropolitan Tsukiji Maternity Hospital

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Other Title
  • HTLV-Iの母子感染初期にみられた血中IL-2およびsIL-2Rの増加について
  • HTLV-1の母子感染初期にみられた血中IL-2およびsIL-2Rの増加について
  • HTLV-1 ノ ボシ カンセン ショキ ニ ミラレタ ケッチュウ IL-2

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Abstract

In our laboratory, children born to women are known to be infected with Human T-cell Leukemia Virus type-1 (HTLV-I) have been followed using, detect of gean by PCR and antibodyWestern Blot Assay (WB) and Immunofluorescence Assay (IFA) test from 1990 through 1996. Four children out of 123 delivery cases have been confirmed to be infected with HTLV-I.<BR>We analyzed the corelation between the concentration of cytokines (IL-2, sIL-2R, IFN-γ) and HTLV-I infection. IL-2 and sIL-2R in sera increased after HTLV-I infection. There was nocorelation between the concentration of IFN-γ and HTLV-I infection. These result suggested that detection of IL-2 and sIL-2R might be the marker of HTLV-I infection.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 72 (1), 17-24, 1998

    The Japanese Association for Infectious Diseases

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