Hepatitis B Virus Variants in Patients with Acute Hepatitis in whom Various Clinical Forms Develop

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  • FUJISE Kiyotaka
    Department of Internal Medicine (Kashiwa Hospital) The Jikei University School of Medicine
  • SUZUKI Kenji
    Department of Internal Medicine (Kashiwa Hospital) The Jikei University School of Medicine
  • NAITO Yoshihiko
    Department of Internal Medicine (Kashiwa Hospital) The Jikei University School of Medicine
  • NIIYA Minoru
    Department of Internal Medicine (Kashiwa Hospital) The Jikei University School of Medicine
  • ISHIKAWA Tomohisa
    Department of Internal Medicine (Kashiwa Hospital) The Jikei University School of Medicine
  • TAKAHASHI Hiroki
    Department of Internal Medicine (Kashiwa Hospital) The Jikei University School of Medicine
  • HOSHINA Sadayori
    Department of Laboratory Medicine, The Jikei University School of Medicine
  • SAITO Atsushi
    Department of Internal Medicine (Kashiwa Hospital) The Jikei University School of Medicine
  • WATANABE Reijiro
    Department of Internal Medicine (Kashiwa Hospital) The Jikei University School of Medicine

Bibliographic Information

Other Title
  • B型急性肝炎各種病型における変異ウイルスの関与
  • Hepatitis B Virus Variants in Patients

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Abstract

Ten patients who suffered from acute hepatitis with various clinical forms due to hepatitis B virus (HBV) were studied. HBV variants with a mutation in the precore region were dominant in two patients with fulminant hepatitis and in a patient with the most severe acute hepatitis. However, these mutant viruses were not detected in a patient who had the fulminant form of acute HBV infection on chronic liver damage or in most patients who had severe acute hepatitis. Furthermore, mutant viruses were also not detected in a patient with complicating myopathy and in one who had an atypical clinical course with three transaminase peaks. These results suggest that precore mutants may be involved in the pathogenesis of some cases of severe acute hepatitis, the same as for fulminant hepatitis, but not in other clinical forms of acute hepatitis.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 72 (1), 67-74, 1998

    The Japanese Association for Infectious Diseases

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