Investigation of the Influence of Hemodialysis Membranes and Factors Associated with Hemodialysis on Serum (1→3)-β-D-glucan

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  • YOSHIDA Kohichiroh
    Division of Respiratory Diseases, Department of Internal Medicine, Kawasaki Medical School
  • NAKAJIMA Masamitsu
    Division of Respiratory Diseases, Department of Internal Medicine, Kawasaki Medical School
  • YAMASAKI Masaomi
    Present Institute of Medical Science, St. Marianna University
  • KITANO Yuichi
    Division of Nephrology, Department of Internal Medicine, Kawasaki Medical School
  • NIKI Yoshihito
    Division of Respiratory Diseases, Department of Internal Medicine, Kawasaki Medical School
  • OHSAWA Gengo
    Division of Nephrology, Department of Internal Medicine, Kawasaki Medical School
  • MATSUSHIMA Toshiharu
    Division of Respiratory Diseases, Department of Internal Medicine, Kawasaki Medical School

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Other Title
  • 各種透析膜及び透析関連因子が血清 (1→3)-β-D-グルカン値に及ぼす影響についての検討
  • カクシュ トウセキ マク オヨビ トウセキ カンレン インシ ガ ケッセイ 1
  • Investigation of the Influence of Hemodialysis Membranes and Factors Associated with Hemodialysis on Serum (1^|^rarr;3)-^|^beta;-D-glucan

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Abstract

The measurement of serum (β3)-β-D-glucan (β-glucan) is commonly used in the clinical stage. Although it has been considered very useful in the carly diagnosis of deep mycosis, it is influenced by several factors, one of which is hemodialysis. Therefore, we decided to investigate clinically the influence of hemodialysis membranes on serum β-glucan. Plasma samples were collected from 26 patients receiving hemodialysis in Kawasaki Medical School Hospital. The kinds of hemodialysis membranes examined were four synthetic polymers and three natural polymers. We also measured β-glucan in five washing liquids used in the hemodialysis circuit, five dialyzates, two sodium heparin and two filling liquids for wet type dialyzers to investigate the influence of other factors associated with hemodialysis on serum β-glucan. Elevations of β-glucan were observed in some cases treated by hemodialysis apparatus using a saponified cellulose acetate membrane. But, in all cases treated by hemodialysis using a cellulose triacetate membrane, slight elevations of β-glucan were observed. No significant increases in β-glucan after hemodialysis were observed in the cases treated by hemodialysis using a synthetic polymer membrane. Elevations of β-glucan in sodium heparin and in one of the filling liquids for the wet type dializer were observed. We, therefore, concluded that there are some other factors having an effect on serum β-glucan besides the hemodialysis membrane in the patients treated by hemodialysis.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 72 (3), 245-248, 1998

    The Japanese Association for Infectious Diseases

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