HIV-1感染者血清中の逆転写酵素活性阻止抗体の動態  [in Japanese] Studies for Dynamrcs of Reverse Transcriptase Inhibiting Antibody in Sera from HIV-1 Infected Individuals  [in Japanese]

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Abstract

HIV-1由来の逆転写酵素活性阻止抗体 (RTI) はほとんどのHIV-1感染者血清中に存在し, これまで, RTIにはBinding Inhibition (BI) 抗体やpolymerization Inhibition (PI) 抗体の存在が明らかとされ, これら抗体と病態との関わりが示唆されてきた.今回, HIV-1感染者血清を検体として, このRTI, BI, PI抗体を測定した.その結果, PI抗体価は感染者全体で一様に分布したのに対してBI抗体は高い抗体価に偏極化していた.また, 各病期ごとには抗体価に有意差は認められなかったが, RTIとBI抗体は無症候期からAIDSへと進行するに従い抗体価が高値と低値へ両極化した.さらに同一感染者における各抗体価の経時的変化は, 測定検体が全て無症候期であったにも関わらず, 期間中変化しない感染者と, 上昇または低下した感染者が存在することが明らかとなった.これらの結果から, 病期を規定する要因には, RTI以外に複数存在し, また, BIおよびPI抗体価は, 同じ病期にあってもその変動が多様であったことから, その要因として, 感染から発症までの期間, 予後や薬剤耐性ウイルスの出現など病期以外の要因が関わっている可能性が示唆された.

Antibodies inhibiting human immunodeficiency virus type 1 (HIV-1) reverse transcriptase activity (RTI-antibody), Binding inhibition antibody (BI-antibody) and polymerization inhibition antibody (PI-antibody) were investigated for their ability to inhibiting RT activity in 248 HIV-1 infected individuals and 99 healthy individuals. In BI-antibody, high titer samples were determined more in than in RTI-and PI-antibodies. No significance was indicated between AC, ARC and AIDS is any antibody, however, progression from AC to AIDS was poled to high titer and low titer in RTI-and BI-antibodies. Moreover, time course of each antibody levels in the same infected individuals were resulted in no change, going up or down through all the experimental term, though all samples were collected in AC. These results were suggested that the determination factor of each stage in HIV progression would be multiple, and that the various dynamics of RTI-, BI-and PI-antibodies in the same infected individuals might be caused in the term from HIV infection to AIDS progression, prognosis or appearing of the drug resistant strain but stages of the disease.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 72(7), 694-700, 1998-07-20

    The Japanese Association for Infectious Diseases

References:  12

Codes

  • NII Article ID (NAID)
    10008718392
  • NII NACSIS-CAT ID (NCID)
    AN00047715
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    03875911
  • NDL Article ID
    4536820
  • NDL Source Classification
    ZS9(科学技術--医学--病理学・微生物学・寄生虫学・感染・免疫学・血清学・アレルギー)
  • NDL Call No.
    Z19-193
  • Data Source
    CJP  NDL  J-STAGE 
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