Clinical Efficacy of Fosfomycin in Combination with Sulbactam/Cefoperazone in the Treatment of Severe Infections Complicated to Blood Dyscrasia

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  • KITAMURA Kiyoshi
    Department of Laboratory Medicine, Faculty of Medicine, University of Tokyo
  • HIRAI Hisamaru
    The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • HOSOYA Noriko
    The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • SUGAI Masao
    The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • KARASAWA Masamitu
    The Third Department of Internal Medicine, Gunma University School of Medicine
  • NARUSE Takuji
    The Third Department of Internal Medicine, Gunma University School of Medicine
  • MIURA Yasusada
    Division of Hematology, Department of Medicine, Jichi Medical School
  • OHMINE Ken
    Division of Hematology, Department of Medicine, Jichi Medical School
  • TAKAGI Syojiro
    Division of Hematology, Department of Medicine, Jichi Medical School, Omiya Medical Center
  • HIRASHIMA Kunitake
    The First Department of Internal Medicine, Saitama Medical School
  • BESSHO Masami
    The First Department of Internal Medicine, Saitama Medical School
  • FUKUDA Masataka
    The First Department of Internal Medicine, Saitama Medical School
  • KAWAI Nobutaka
    The First Department of Internal Medicine, Saitama Medical School
  • DAN Kazuo
    The Third Department of Internal Medicine, Nippon Medical School
  • AN Emi
    The Third Department of Internal Medicine, Nippon Medical School
  • HOSHINO Tetsuo
    The Third Department of Internal Medicine, Nippon Medical School
  • OSHIMI Kazuo
    Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine
  • NOGUCHI Masaaki
    Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine
  • EGASHIRA Motoki
    Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine
  • IKEDA Yasuo
    Department of Internal Medicine, Keio University School of Medicine
  • KIZAKI Masahiro
    Department of Internal Medicine, Keio University School of Medicine
  • TOYAMA Keisuke
    The First Department of Internal Medicine, Tokyo Medical College
  • MIYAZAWA Keisuke
    The First Department of Internal Medicine, Tokyo Medical College
  • NAGASU Masaya
    The First Department of Internal Medicine, Tokyo Medical College
  • INATOMI Yuka
    The First Department of Internal Medicine, Tokyo Medical College
  • KURIYAMA Yuzuru
    The First Department of Internal Medicine, Tokyo Medical College
  • IWASE Osamu
    The First Department of Internal Medicine, Tokyo Medical College
  • MIZOGUCHI Hideaki
    Department of Hematology, Tokyo Women's Medical College
  • KOBAYASHI Shoko
    Department of Hematology, Tokyo Women's Medical College
  • TSURUOKA Nobuyoshi
    Department of Hematology, Showa University School of Medicine
  • TOMOYASU Shigeru
    Department of Hematology, Showa University School of Medicine
  • NAKAMAKI Tsuyoshi
    Department of Hematology, Showa University School of Medicine
  • AKIMOTO Yoshihisa
    Department of Hematology, Showa University School of Medicine
  • KAKIMOTO Tsunayuki
    Department of Hematology, Showa University School of Medicine
  • MUTO Yoshitomo
    Department of Hematology, Toranomon Hospital
  • UEYAMA Junichi
    Department of Hematology, Toranomon Hospital
  • TOGAWA Atsushi
    Division of Internal Medicine, International Medical Center of Japan
  • MIWA Akiyoshi
    Division of Internal Medicine, International Medical Center of Japan
  • NAGAI Mari
    Division of Internal Medicine, International Medical Center of Japan
  • URABE Akio
    Division of Hematology, Kanto Teishin Hospital
  • ENDO Mitsue
    Division of Hematology, Kanto Teishin Hospital
  • MORI Mayumi
    Division of Hematology, Tokyo Metropolitan Geriatric Hospital
  • KURAMOTO Ken
    Division of Hematology, Tokyo Metropolitan Geriatric Hospital
  • KIKUKAWA Masayuki
    Division of Hematology, Tokyo Metropolitan Geriatric Hospital
  • NAKAMURA Noriko
    Division of Hematology, Tokyo Metropolitan Geriatric Hospital
  • SUZUKI Kenshi
    Department of Hematology, Japanese Red Cross Medical Center
  • INOUE Yasuyuki
    Department of Hematology, Japanese Red Cross Medical Center
  • SAWANOBORI Masakazu
    Department of Hematology, Japanese Red Cross Medical Center
  • NAKAGAWA Yasuaki
    Department of Hematology, Japanese Red Cross Medical Center
  • ISHIKAWA Kyozo
    Second Department of Internal Medicine, Kyorin University School of Medicine
  • KAWANO Koichi
    Second Department of Internal Medicine, Kyorin University School of Medicine
  • HOMORI Masashi
    Second Department of Internal Medicine, Kyorin University School of Medicine
  • MURAI Yoshiro
    Department of Hematology, Tokyo Metropolitan Tama Geriatric Hospital
  • MIZUTANI Ryoko
    Department of Hematology, Tokyo Metropolitan Tama Geriatric Hospital
  • NAKAMURA Kyoko
    Department of Hematology, Tokyo Metropolitan Tama Geriatric Hospital
  • OMINE Mitsuhiro
    Division of Hematology, Department of Internal Medicine, Showa University Fujigaoka Hospital
  • FUJIWARA Hikaru
    Division of Hematology, Department of Internal Medicine, Showa University Fujigaoka Hospital
  • CHIBA Shyozo
    The Department of Internal Medicine, Yokohama Rosai Hospital
  • HIRASAWA Akira
    The Department of Internal Medicine, Yokohama Rosai Hospital

Bibliographic Information

Other Title
  • 血液疾患合併重症感染症に対するFosfomycinとSulbactam/Cefoperazoneの併用療法における臨床効果
  • ケツエキ シッカン ガッペイ ジュウショウ カンセンショウ ニ タイスル Fo
  • Working Group of Kanto Combination Therapy for F0M+SBT/CPZ
  • 「関東FOM+SBT/CPZ併用療法研究」

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Abstract

In the treatment of severe infections complicated to blood dyscrasia, the efficacy and usefulness of fosfomycin (FOM) in combination with sulbactam (SBT)/cefoperazone (CPZ) were compared between patients receiving FOM in the first followed by SBT/CPZ (Group A) and those receiving both drugs simultaneously (Group B). The following results were obtained.<BR>1. The efficacy rate was 56.3% for Group A and 47.9% for Group B, with no significant difference.<BR>2. The efficacy for patients suspected of the presence of septicemia, the efficacy rate was 57.9% for Group A and 54.3% for Group B, with no significant difference.<BR>3. As for underlying disease, patients with acute myelogenous leukemia were most prevailing. In these patients, the efficacy rate was 57.1% for Group A and 27.3% for Group B, with no statistically significant difference. However, the efficacy rate tended to be higher in Group A.<BR>4. The administration of antibiotics was effective to restore the neutrophil count to 501/μl or higher in 77.8% and 45.5% of the cases for Groups A and B, respectively, with significantly higher efficacy for Group A.<BR>5. In the safety evaluation a total of 115 cases were included. Side effects and laboratory abnormalities were seen in 3 cases each, but none of them were serious in degree.<BR>From these results, it was confirmed that the combination therapy consisting of administra-tion of FOM followed by SBT/CPZ with some interval is effective for severe inf ections complicated to blood dyscrasia.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 72 (7), 761-770, 1998

    The Japanese Association for Infectious Diseases

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