Clinical Study on Mechanism of<I>Pneumocystis carinii</I>Pneumonia by Polymerase Chain Reaction

• HASHIMOTO Atsuro

  The Second Department of Internal Medicine, Oita Medical University

• MIZUNOE Shunji

  The Second Department of Internal Medicine, Oita Medical University

• TOKIMATSU Issei

  The Second Department of Internal Medicine, Oita Medical University

• NAKAMA Kaoru

  The Second Department of Internal Medicine, Oita Medical University

• YAMAGATA Eiji

  The Second Department of Internal Medicine, Oita Medical University

• YAMAKAMI Yuriko

  The Second Department of Internal Medicine, Oita Medical University

• NAGAI Hiroyuki

  The Second Department of Internal Medicine, Oita Medical University

• NASU Masaru

  The Second Department of Internal Medicine, Oita Medical University

Bibliographic Information

Other Title

• Polymerase Chain Reaction(PCR)法を用いた<I>Pneumocystis carinii</I>肺炎発症機序に関する検討
• Polymerase Chain Reaction(PCR)法を用いたPneumocystis carinii肺炎発症機序に関する検討
• Polymerase Chain Reaction PCR ホウ オ モチイタ
• Clinical Study on Mechanism ofPneumocystis cariniiPneumonia by Polymerase Chain Reaction

Abstract

Pneumocystis carinii is a human respiratory pathogen which causes fatal pneumonia in patients under immunosuppressed or immune deficient conditions. Recent work have documented the usefulness of the polymerase chain reaction (PCR) method in the detection of P. carinii from clinical samples. Therefore, we described our experience in using PCR method in the detection of P. carinii from respiratory samples. In our study, bronchial washing or BALF were good for diagnosis of P. carinii pneumonia (PCP) by PCR. However, PCR method in the detection of P. carinii from swab or sputum was too sensitive because smal numbers of P. carinii organisms might be insignificant in causing the disease. It might reveal colonization or asymptomatic carrier state in the upper respiratory tract. Therefore, our result suggested that colonization or asymptmatic carrier state in the upper respiratory tract could eventually evolve into PCP. This would also facilitate basic progress in the pathology or epidemiology of P. carinii infection. In addition, an usefulness of prophylactic therapy for PCP was documented by PCR.

Journal

• Kansenshogaku Zasshi

  Kansenshogaku Zasshi 72 (9), 870-875, 1998

  The Japanese Association for Infectious Diseases

Keywords

• PCR
• Pneumocystis carinii
• sulfamethoxazole/trimethoprim
• colonization

Details

• CRID: 1390282680025729536
• NII Article ID: 130004112672
• NII Article ID: 10008718780
• NII Book ID: AN00047715
• DOI: 10.11150/kansenshogakuzasshi1970.72.870
• ISSN: 1884569X
• ISSN: 03875911
• NDL BIB ID: 4572665
• PubMed: 9796184
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4572665
• Web Site: https://search.jamas.or.jp/link/ui/1999061104
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed