Girl with Systemic Onset Juvenile Rheumatoid Arthritis Suspected to be due to Human Parvovirus B19 Infection

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  • WADA Yasuyuki
    Department of Pediatrics, Kashiwa Hospital, Tokyo Jikei University School of Medicines
  • KOBAYASHI Minako
    Department of Pediatrics, Kashiwa Hospital, Tokyo Jikei University School of Medicines
  • KUBO Masakatsu
    Department of Pediatrics, Kashiwa Hospital, Tokyo Jikei University School of Medicines

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  • Human Parvovirus B19感染症が発症に関与したと考えられた全身型若年性関節リウマチの1女児例

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Abstract

We encountered a case of a girl where Human Parvovirus B19 infection was considered to have been concerned with the development of systemic type juvenile rheumatoid arthritis (JRA). While the affected child did not show any evident infectious erythema-like findings, changes in the serum antibody titer by the EIA method presented the pattern of first infection. During the clinical course the condition of the disease as JRA was serious and hemophagocytic syndrome developed concurrently. Furthermore, the resistance to the treatment was also noted. So the patient was treated with prednisolone combined with low dose weekly MTX therapy. The possibility of Human parvovirus B19 being concerned with the development of rheumatoid arthritis in one form or another has been suggested in recent years. In the disease type with systemic angititis as main pathophysiology, which is called systemic JRA we encounted this time, it is not clear how Human Parvovirus B19 was concerned with the development of this disease, but it appeared to hold a key position in studying pathophysiology of the development.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 71 (5), 468-473, 1997

    The Japanese Association for Infectious Diseases

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