海外での動物咬傷被害者が現地で接種を受けた狂犬病ワクチンの種類  [in Japanese] Types of Rabies Vaccines which Were Locally Injected to the Subjects Bitten by Animals Abroad  [in Japanese]

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Abstract

近年狂犬病常在地で狂犬病危険動物に咬まれて帰国し, 狂犬病ワクチン接種の目的で当院を受診する人が増加している.WHOは, 狂犬病危険動物に咬まれた場合, 傷を石鹸と流水で十分洗浄したのち, ヒト抗狂犬病免疫グロブリンを注射し, 組織培養狂犬病ワクチンを0, 3, 7, 14, 30, 90日の6回接種するように勧告している.しかし, 組織培養狂犬病ワクチンは高価であり, 全世界どこでも使用されているとはかぎらない.当院を受診した咬傷被害者が現地で狂犬病ワクチンなどの接種を受けたか否か, 接種を受けた場合には, どのような種類の狂犬病ワクチンが用いられていたかを調査した.受診者の約半数は現地で狂犬病ワクチン接種を受けていた.また接種証明書やワクチンの空き箱で, 接種されたワクチンの種類が判明した40例のうち38例は組織培養不活化狂犬病ワクチンの接種を受けていたが, センプル型ワクチン, 乳のみマウスワクチンの接種を受けた者が1名ずついた.日本で曝露後免疫を続行する際に, すでに接種された狂犬病ワクチンのタイプを知ることは, 十分な抗体産生を誘導して, 狂犬病の発病を阻止するうえで重要である.したがって, まだ古い型の感染動物脳由来狂犬病ワクチンを接種している地域があることを医師も旅行者も知っておくべきである.

In recent years there have been a number of subjects who were bitten by supposed rabid animals in foreign rabies-epizootic countries and visited our hospital to receive post-exposure therapy after their return to Japan. WHO recommends immediate washing of the wound with soap and water, applicatun of human anti-rabies immunoglobulin and administration of tissueculture rabies vaccine at 0, 3, 7, 14, 30, and 90 days after exposure. However, tissue-culture vaccines, are expensive and they are not always used in all parts of the world. The author checked whether the victims of animal bite were injected with rabies vaccines abroad or not and investigated the type of rabies vaccine when they were vaccinated. About a half of the consulted victims were locally injected with rabies vaccine. By mean of certificates of inoculation or empty boxes of vaccine, types of rabies vaccines were proved in 40 subjects of which 38 received tissue-culture vaccines. Semple-type vaccine was administered to one subject and suckling mouse vaccine was done to another one. When post-exposure prophylaxis was continued after return to Japan, it is important to know the sort of rabies vaccine injected abroad, because brain-tissue vaccines are less effective in inducing antibody than tissue-culture vaccines. Consequently both physicians and travelers should keep in mind that even now brain-tissue vaccines are used in some areas of the world.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 71(8), 751-755, 1997-08-20

    The Japanese Association for Infectious Diseases

References:  9

Codes

  • NII Article ID (NAID)
    10008721388
  • NII NACSIS-CAT ID (NCID)
    AN00047715
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    03875911
  • NDL Article ID
    4306171
  • NDL Source Classification
    ZS9(科学技術--医学--病理学・微生物学・寄生虫学・感染・免疫学・血清学・アレルギー)
  • NDL Call No.
    Z19-193
  • Data Source
    CJP  NDL  J-STAGE 
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