造血器障害患者の穎粒球減少期におけるニューキノロン剤の感染予防効果の検討 : ST合剤単独とCiproHoxacin+ST合剤併用の比較試験  [in Japanese] Chemoprophylaxis of Bacterial Infections in Granulocytopenic Patients with New Quinolone; A Comparison of Trimethoprim-sulfarnethoxazole (ST) : Alone with ST Plus Ciprofloxacin  [in Japanese]

Access this Article

Author(s)

Abstract

造血器障害患者の顆粒球減少期におけるnew quinolone剤の細菌感染症併発予防効果を検討する目的でciprofloxacin (CPFX) を試験薬としてtrimethoprim-sulfamethoxazole (ST) 単独とCPFX+ST併用との無作為比較試験を行った.その結果, ST単独群では24例中17例 (70.8%) に, CPFX+ST併用群では29例中9例 (31.0%) に38℃ 以上の発熱を認め, CPFX+ST併用群で有意 (p<0.005) に優れた予防効果を認めた.ST単独では最少顆粒球数が250/μl以上の症例においては有効 (5例/5例) であったが, 250/μl以下の症例ではほとんど感染予防効果は認められなかった (2例/19例).一方, CPFX+ST併用では最少顆粒球数にかかわらず有効であった.また, 両群とも臨床上問題となるような副作用は出現しなかった.以上の結果より, new quinolone剤であるciprofloxacinとST合剤との併用投与は造血器障害患者の顆粒球減少期における感染予防に有効で, 特に, 急性白血病の症例等の最少顆粒球値の低い症例でその効果が顕著であると考えられた.

Fifty-three granulocytopenic patients were studied in a randomized trial comparing trimethoprim-sulfamethoxaxole (ST) alone with ST+ciprofloxacin (CPFX) for prevention of bacterial infections.Seventeen febrile episodes occurrred in 24 patients receiving ST alone, and 9 febrile episodes occurred in 29 patients receiving ST+CPFX. ST+CPFX was significantly effective than ST alone (p<0.005).Although ST alone was effective to prevent infections in moderately granulocytopenic patients, it could not prevent infections in severely granulocytopenic patients whose minimal granulocyte count was less than 250/μl during prophylactic treatment.In contrast, ST+CPFX was effective in severely as well as in moderately granulocytopenic patients.Clinically significant adverse reactions were not observed in both regimens.<BR>These results suggest that combination with ST and CPFX is more efficacious than ST alone for the prevention of bacterial infections in granulocytopenic patients.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 69(1), 28-32, 1995-01-20

    The Japanese Association for Infectious Diseases

References:  11

Codes

  • NII Article ID (NAID)
    10008725172
  • NII NACSIS-CAT ID (NCID)
    AN00047715
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    03875911
  • NDL Article ID
    3604460
  • NDL Source Classification
    SC191(感染症)
  • NDL Source Classification
    ZS9(科学技術--医学--病理学・微生物学・寄生虫学・感染・免疫学・血清学・アレルギー)
  • NDL Call No.
    Z19-193
  • Data Source
    CJP  NDL  J-STAGE 
Page Top