Studies on Maternal Transmission of HIV-1

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  • TABEI Yukiko
    Department of Microbiology, Division of Virology, Tokyo Metropolitan Research Laboratory of Pubulic Health
  • SADAMASU Kenji
    Department of Microbiology, Division of Virology, Tokyo Metropolitan Research Laboratory of Pubulic Health
  • MORI Kohji
    Department of Microbiology, Division of Virology, Tokyo Metropolitan Research Laboratory of Pubulic Health
  • MONMA Kimio
    Department of Microbiology, Division of Virology, Tokyo Metropolitan Research Laboratory of Pubulic Health
  • SEKINE Hiromasa
    Department of Microbiology, Division of Virology, Tokyo Metropolitan Research Laboratory of Pubulic Health
  • KUDOH Yasuo
    Department of Microbiology, Division of Virology, Tokyo Metropolitan Research Laboratory of Pubulic Health
  • MIYAZAWA Yutaka
    Tokyo Metropolitan Ohtsuka Hospital
  • OKADA Kiyoshi
    Tokyo Metropolitan Ohtsuka Hospital

Bibliographic Information

Other Title
  • HIV-1母児感染についての調査成績
  • HIV-1 ボジ カンセン ニ ツイテ ノ チョウサ セイセキ

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Abstract

To investigate HIV-1 transmission from mother to child, samples taken from 3 HIV-1 sero-positive pregnant mothers, 3 children born by caesareans from their mothers and therapeutic abortion from 2 HIV-1 sero-positive mothers were tested for HIV-1 antiboy by westernblot, p24 antigen by antigen caputured ELISA, proviral DNA by Nested-PCR and isolation of HIV-1 virus from peripheral blood, cord blood, amniotic fluid and placenta. HIV-1 proviral DNA was detected in the peripheral blood of all mothers, but p24 antigen and virus isolation were not detected. None of the HIV-1 markers, except for antibody, was detected in the samples from their children and placenta.<BR>These facts strongly suggest that there was no HIV-1 transmission from motherto child.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 69 (8), 858-863, 1995

    The Japanese Association for Infectious Diseases

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