A Study of Defensins in Bronchoalveolar Lavage Fluid in Patients with Diffuse Panbronchiolitis

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  • MUKAE Hiroshi
    The Third Department of Internal Medicine, Miyazaki Medical College
  • ASHITANI Jun-ichi
    The Third Department of Internal Medicine, Miyazaki Medical College
  • NAKAZATO Masamitsu
    The Third Department of Internal Medicine, Miyazaki Medical College
  • TANIGUCHI Haruko
    The Third Department of Internal Medicine, Miyazaki Medical College
  • DATE Yukari
    The Third Department of Internal Medicine, Miyazaki Medical College
  • IHI Toshihiko
    The Third Department of Internal Medicine, Miyazaki Medical College
  • SHIOMI Kazutaka
    The Third Department of Internal Medicine, Miyazaki Medical College
  • MASHIMOTO Hideo
    The Third Department of Internal Medicine, Miyazaki Medical College
  • MATSUKURA Shigeru
    The Third Department of Internal Medicine, Miyazaki Medical College
  • KADOTA Jun-ichi
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
  • KOHNO Shigeru
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
  • HARA Kohei
    The Second Department of Internal Medicine, Nagasaki University School of Medicine

Bibliographic Information

Other Title
  • びまん性汎細気管支炎の気管支肺胞洗浄液中デフェンシンに関する検討
  • ビマンセイ ハン サイ キカンシエン ノ キカンシ ハイホウ センジョウエキチ

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Abstract

We estimated defensins, antimicrobial and cytotoxic peptides localized in azurophil granules of neutrophils, in bronchoalveolar lavage fluid (BALF) in patients with diffuse panbronchiolitis (DPB). BALF from DPB patients contained a higher concentration of defensins than those from patients with idiopathic pulmonary fibrosis and healthy volunteers. A significant correlation was observed between the concentration of defensins and the number of neutrophils, the concentration of interleukin-8 or neutrophil elastase in BALF of DPB patients. An immunohistochemical study of open-lung biopsy specimens from DPB patients showed a strong immunoreactivity for defensins in neutrophils and mucinous exudates in the airways and in the surface of bronchiolar epithelial cells. After treatment with macrolide antibiotics, significant reductions in the concentrations of defensins, IL-8 and neutrophil numbers in BALF of DPB patients were observed. These findings suggest that the lung injury in DPB could be caused by defensins released by neutrophils accumulated in the airways.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 69 (9), 975-981, 1995

    The Japanese Association for Infectious Diseases

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