Appearance of Antibacterial Activity of Oxacillin against Methicillin Resistant <I>Staphylococcus aureus</I> (MRSA) in the Presence of Catechin

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  • TAKAHASHI Osahiko
    Department of Microbiology and Immunology, Showa University School of Medicine
  • CAI Zhe
    Department of Microbiology and Immunology, Showa University School of Medicine
  • TODA Masako
    Department of Microbiology and Immunology, Showa University School of Medicine
  • HARA Yukihiko
    Food Research Laboratories, Mitsui Norin Co.
  • SHIMAMURA Tadakatsu
    Department of Microbiology and Immunology, Showa University School of Medicine

Bibliographic Information

Other Title
  • カテキンによるMRSAに対するオキサシリンの抗菌作用出現
  • カテキン ニヨル MRSA ニ タイスル オキサシリン ノ コウキン サヨウ
  • Appearance of Antibacterial Activity of Oxacillin against Methicillin Resistant Staphylococcus aureus (MRSA) in the Presence of Catechin

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Abstract

We previously reported that tea catechin shows bactericidal activity against various bacteria including methicillin resistant Staphylococcus aureus (MRSA) and that bactericidal catechin damages the lipid bilayer of bacterial cell membranes. Here we describe that oxacillin (MPIPC) shows antibacterial activity against MRSA in the presence of catechin below MIC.<BR>Twenty clinical isolates of MRSA were examined by a cup method. In the absence of catechin, MPIPC even at a concentration of 40, μg/ml did not show antibacterial activity against all isolates of MRSA. However, when catechin below MIC (25-100, μg/ml) was mixed with the agar medium, MPIPC (5-12.5, μg/ml) showed antibacterial activity against all MRSA isolates. By counting the numbers of viable bacteria in a broth culture, only MPIPC (5, μg/ml) or catechin (100, μg/ml) showed similar growth curves to the control. But addition of both MPIPC and catechin reduced the number of viable bacteria to 1/100-1/10000 after 24 hours of cultures.<BR>Besides MPIPC, in the presence of catechin below MIC methicillin (12.5, μg/ml), aminobenzylpenicillin (32 μg/ml), tetracycline (2.5 μg/ml), and chloramphenicol (12.5μg/ml) showed antibacterial activities against multiple drug resistant MRSA to antibiotics mentioned above.<BR>These findings suggest a possible use of catechin in the treatment of MRSA infection.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 69 (10), 1126-1134, 1995

    The Japanese Association for Infectious Diseases

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