Studying the Dopaminergic System with Transfected Receptors

• Yamaguchi Ikuyo

  Department of Pathology, the University of Virginia Health Sciences Center

• Walk Scott F.

  Department of Pathology, the University of Virginia Health Sciences Center

• Felder Robin A.

  Department of Pathology, the University of Virginia Health Sciences Center

Abstract

Dopamine receptors are responsible for diverse effects within and outside the central nervous system. The five dopamine receptors that have been cloned (D_1A, D_1B also known as D₅, D₂, D₃, and D₄) belong to two major families; the D₁ like and D₂ like dopamine receptors. The D₁ like receptors are linked to the stimulation while D₂ like receptors are linked to the inhibition of adenylyl cyclase. The physiologic role of the dopamine receptors has been difficult to decipher because several of the subtypes co-exist in the same tissue. However, studies of receptors artificially expressed using transfected cDNA have revealed some of the biochemical mechanisms unique to each dopamine receptor subtype. (Hypertens Res 1995; 18 Suppl. I: S19-S22)

Journal

• Hypertension Research

  Hypertension Research 18 (SupplementI), S19-S22, 1995

  The Japanese Society of Hypertension

Keywords

• dopamine receptor
• transfected cell
• receptor synergism

Details

• CRID: 1390282679696257024
• NII Article ID: 10008735251
• NII Article ID: 130003399341
• NII Book ID: AA10847079
• DOI: 10.1291/hypres.18.supplementi_s19
• ISSN: 13484214
• ISSN: 09169636
• Web Site: https://search.jamas.or.jp/link/ui/1996153624
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed