Studying the Dopaminergic System with Transfected Receptors

• Yamaguchi Ikuyo

  Department of Pathology, the University of Virginia Health Sciences Center

• Walk Scott F.

  Department of Pathology, the University of Virginia Health Sciences Center

• Felder Robin A.

  Department of Pathology, the University of Virginia Health Sciences Center

抄録

Dopamine receptors are responsible for diverse effects within and outside the central nervous system. The five dopamine receptors that have been cloned (D_1A, D_1B also known as D₅, D₂, D₃, and D₄) belong to two major families; the D₁ like and D₂ like dopamine receptors. The D₁ like receptors are linked to the stimulation while D₂ like receptors are linked to the inhibition of adenylyl cyclase. The physiologic role of the dopamine receptors has been difficult to decipher because several of the subtypes co-exist in the same tissue. However, studies of receptors artificially expressed using transfected cDNA have revealed some of the biochemical mechanisms unique to each dopamine receptor subtype. (Hypertens Res 1995; 18 Suppl. I: S19-S22)

収録刊行物

• Hypertension Research

  Hypertension Research 18 (SupplementI), S19-S22, 1995

  日本高血圧学会

キーワード

• dopamine receptor
• transfected cell
• receptor synergism

詳細情報

• CRID: 1390282679696257024
• NII論文ID: 10008735251
• NII論文ID: 130003399341
• NII書誌ID: AA10847079
• DOI: 10.1291/hypres.18.supplementi_s19
• ISSN: 13484214
• ISSN: 09169636
• Web Site: https://search.jamas.or.jp/link/ui/1996153624
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可