Activation of Renal Dopamine System by Physical Exercise
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- Arakawa Kikuo
- Department of Internal Medicine, School of Medicine, Fukuoka University
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- Miura Shin-ichiro
- Department of Internal Medicine, School of Medicine, Fukuoka University
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- Koga Manabu
- Department of Internal Medicine, School of Medicine, Fukuoka University
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- Kinoshita Akio
- Department of Internal Medicine, School of Medicine, Fukuoka University
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- Kiyonaga Akira
- Department of Internal Medicine, School of Medicine, Fukuoka University
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Abstract
Physical exercise is one of the life-style modifications used for lowering blood pressure. Except for diminished norepinephrine spill over, the mechanism by which physical exercise exerts its effects was not known. Based on our preliminary finding that the reduction of blood pressure was inversely correlated to the baseline plasma renin activity, we have consequently revealed that mild exercise reduces plasma volume and hence the cardiac index. In order to elucidate the mechanism, we have investigated all possible parameters relevant to plasma volume regulation. Among them, urinary free dopamine and urinary active kallikrein increased in the early stages (weeks 2-4) while atrio-natriuretic factor (week 4) and endogeneous ouabain-like substance (EOLS) consequently (weeks 7-10) decreased. Serum taurine increased and plasma norepinephrine decreased in the late stages. The conclusion reached is that mild exercise seems to first activate the renal dopamine and kallikrein systems and second trigger other mechanism, such as an increase in taurine and decreases in EOLS and norepinephrine. (Hypertens Res 1995; 18 Suppl. I: S73-S77)
Journal
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- Hypertension Research
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Hypertension Research 18 (SupplementI), S73-S77, 1995
The Japanese Society of Hypertension
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Details 詳細情報について
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- CRID
- 1390282679695781248
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- NII Article ID
- 10008735494
- 130003399360
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- NII Book ID
- AA10847079
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- ISSN
- 13484214
- 09169636
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed