Localisation of Dopamine D₁-Like and D₂-Like Receptors in the Pulmonary Vasculature

• Kobayashi Yuta

  the Department of Pharmacology, Shimane Medical University

• Amenta Francesco

  Sezione di Anatomia Umana, Istituto di Farmacologia, Università di Camerino

• Ricci Alberto

  Dipartimento di Scienze Cardiovascolari e Respiratorie, Università "La Sapienza"

• Hattori Keisuke

  the Department of Pharmacology, Shimane Medical University

Bibliographic Information

Other Title

• Localisation of Dopamine D1-Like and D2-Like Receptors in the Pulmonary Vasculature

Abstract

The pharmacological profile and the anatomical localisation of dopamine receptor subtypes were investigated in the rabbit pulmonary vascular bed using combined radioligand binding and light microscope autoradiography techniques. Dopamine D₁-like receptor sites, which probably belong to the dopamine D₁ receptor subtype, were characterized in sections of lung using [³H]-SCH 23390 as a ligand. These sites were located within the tunica intima and the tunica media of large sized intrapulmonary artery branches and in the tunica media of medium sized intrapulmonary artery branches. Dopamine D₂-like receptor sites, which probably belong to the dopamine D₂ receptor subtype, were characterized using [³H]-spiroperidol as a ligand. These sites were located within the tunica adventitia of both extra- and intrapulmonary artery branches. Dopamine D₂-like receptor sites were also found in the tunica adventitia of the human pulmonary artery, but not of the rat pulmonary artery. The different anatomical localization of dopamine D₁ and D₂ receptor subtypes in the pulmonary vasculature suggests that these sites are involved in the modulation of pulmonary vascular tone by interacting with different receptors unevenly distributed throughout the pulmonary vascular bed. (Hypertens Res 1995; 18 Suppl. I: S153-S156)

Journal

• Hypertension Research

  Hypertension Research 18 (SupplementI), S153-S156, 1995

  The Japanese Society of Hypertension

Keywords

• dopamine receptor subtypes
• pulmonary artery
• human
• rabbit
• radioligand binding

Details

• CRID: 1390282679696244352
• NII Article ID: 10008735979
• NII Article ID: 130003399332
• NII Book ID: AA10847079
• DOI: 10.1291/hypres.18.supplementi_s153
• ISSN: 13484214
• ISSN: 09169636
• Web Site: https://search.jamas.or.jp/link/ui/1996153626
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed