Association of Coronary Risk Factors and Endothelium-Dependent Flow-Mediated Dilatation of the Brachial Artery.
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- HASHIMOTO Masayoshi
- Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
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- KOZAKI Koichi
- Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
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- ETO Masato
- Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
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- AKISHITA Masahiro
- Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
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- AKO Junya
- Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
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- IIJIMA Katsuya
- Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
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- KIM Seungbum
- Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
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- TOBA Kenji
- Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
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- YOSHIZUMI Masao
- Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
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- OUCHI Yasuyoshi
- Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo
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抄録
Impaired endothelial function has been reported to be the initial step in atherosclerosis. Some coronary risk factors independently relate to impaired endothelial function. However, few studies have examined the association between coronary risk factors and endothelial function in patients who have multiple risk factors without clinical atherosclerosis. This study was undertaken to elucidate the relationship between accumulation of coronary risk factors and vascular endothelial dysfunction. We examined 101 subjects with one or more coronary risk factors 56.8±1.0 years old and 40 age-matched control subjects without coronary risk factors. We measured brachial artery diameter non-invasively using a 7.5-MHz ultrasound machine at rest, during reactive hyperemia caused by endothelium-dependent vasodilatation, and after sublingual administration of nitroglycerin, which causes endothelium-independent vasodilatation. The percentage change in flow-mediated diameter (%FMD; ΔD/D×100), in subjects with one or more coronary risk factors was significantly lower than that in control subjects (4.8±0.3% vs. 6.7±0.5% p<0.01). Endothelium-independent vasodilatation by nitroglycerin did not differ between the two groups. Endothelial function was impaired according to the accumulation of coronary risk factors. On multiple regression analysis, the number of risk factors, age, and brachial artery diameter at rest showed significant correlation with %FMD. Our results suggest that an accumulation of coronary risk factors was significantly related to impairment of endothelial function. (Hyperfens Res 2000; 23: 233-238)
収録刊行物
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- Hypertension Research
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Hypertension Research 23 (3), 233-238, 2000
日本高血圧学会
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詳細情報 詳細情報について
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- CRID
- 1390001204719268096
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- NII論文ID
- 10008739370
- 130003456424
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- NII書誌ID
- AA10847079
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- COI
- 1:STN:280:DC%2BD3czosFajug%3D%3D
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- ISSN
- 13484214
- 09169636
- http://id.crossref.org/issn/09169636
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- PubMed
- 10821132
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可