Assessment of in vivo Oxidative Stress in Hypertensive Rats and Hypertensive Subjects in Tanzania, Africa

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Author(s)

    • NEGISHI Hiroko
    • Graduate School of Human and Environmental Studies, Kyoto University
    • IKEDA Katsumi
    • Graduate School of Human and Environmental Studies, Kyoto University
    • SAGARA Miki
    • Graduate School of Human and Environmental Studies, Kyoto University
    • KUGA Sachiko
    • Graduate School of Human and Environmental Studies, Kyoto University
    • KANDA Tomo
    • Graduate School of Human and Environmental Studies, Kyoto University
    • LIU Longjian
    • Graduate School of Human and Environmental Studies, Kyoto University
    • NARA Yasuo
    • Graduate School of Integrated Science and Art, University of East Asia
    • YAMORI Yukio
    • Graduate School of Human and Environmental Studies, Kyoto University

Abstract

Oxidative stress has been reported to be involved in not only cardiovascular diseases but in hypertension, which is a major risk for cardiovascular diseases. Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) has been recognized as a sensitive biomarker of oxidative DNA damage and also of oxidative stress. In the present study, we assessed the oxidative stress in human subjects with hypertension and in hypertensive rats. In stroke-prone spontaneously hypertensive rats at the age of 14 weeks, the excretion of urinary 8-OHdG was significantly (<i>p</i><0.05) increased compared with that in age-matched normotensive Wistar-Kyoto rats. Next, we investigated the relationship between oxidative DNA damage and cardiovascular risk factors among Tanzanians aged 46-58 years in a population study carried out in 1998 in at Dar es Salaam, Tanzania, according to the WHO-CARDIAC Study Protocol. Sixty subjects (male/female, 28/32) were selected by SPSS Base 8.0 from those who completed a 24-h urine collection. The 24-h urinary 8-OHdG of the hypertensive subjects (SBP_??_140mmHg and/or DBP_??_90mmHg) was significantly (<i>p</i><0.05) higher than that of the normotensive subjects (SBP<140mmHg and DBP<90mmHg) after adjusting for age and gender (Hypertensives: 17.31±2.0ng/mg creatinine, n=38; Normotensives:10.10±2.64ng/mg creatinine, <i>n</i>=22). Oxidative stress was thought to be involved in hypertensive subjects and in hypertensive rats. (<i>Hypertens Res</i> 2000; 23: 285-289)

Journal

  • Hypertension Research

    Hypertension Research 23(3), 285-289, 2000-05-01

    The Japanese Society of Hypertension

References:  26

Cited by:  6

Codes

  • NII Article ID (NAID)
    10008739561
  • NII NACSIS-CAT ID (NCID)
    AA10847079
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    09169636
  • Data Source
    CJP  CJPref  J-STAGE 
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