Determination of Optimal Blood Pressure for Patients with IgA Nephropathy Based on Renal Histology.
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- OSAWA Yutaka
- Department of Medicine, Niigata University School of Medicine
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- NARITA Ichiei
- Department of Medicine, Niigata University School of Medicine
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- IMAI Naofumi
- Department of Medicine, Niigata University School of Medicine
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- IINO Noriaki
- Department of Medicine, Niigata University School of Medicine
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- IGUCHI Seitaro
- Department of Medicine, Niigata University School of Medicine
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- UENO Mitsuhiro
- Department of Medicine, Niigata University School of Medicine
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- SHIMADA Hisaki
- Department of Medicine, Niigata University School of Medicine
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- NISHI Shinichi
- Department of Medicine, Niigata University School of Medicine
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- ARAKAWA Masaaki
- Department of Medicine, Niigata University School of Medicine
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- GEJYO Fumitake
- Department of Medicine, Niigata University School of Medicine
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Abstract
To evaluate the optimal BP control for patients with IgA nephropathy (IgAN) based on the histologic severity of the nephropathy and the degree of renal dysfunction. We analyzed 332 consecutive renal biopsy specimens and clinical data from patients with IgAN. Patients were divided into three groups based on their BP at the time of biopsy: an optimal BP (SBP<120 mmHg and DBP<80 mmHg), a hypertensive BP (SBP≥140 mmHg and/or DBP≥90 mmHg), and an intermediate BP group. Each biopsy specimen was evaluated for mesangial proliferation, degree of sclerosis and/or hyalinosis of the arterioles and the interlobular artery using a semiquantitative method. Creatinine clearance and the percentage of sclerosed glomeruli were also determined. Both the degree of renal dysfunction and the histologic changes correlated significantly with BP, even in patients with a BP<140/90 mmHg. The patients with an optimal BP at the time of biopsy had significantly less histologic damage with respect to mesangial proliferation and vessel changes than those with an intermediate or hypertensive BP. In the patients with a hypertensive BP, the percentage of sclerotic glomeruli was significantly higher and the creatinine clearance was significantly lower. The optimal BP proposed by the WHO in 1999 prevents histologic evidence of renal damage for patients with IgAN. (Hypertens Res 2001; 24: 89-92)
Journal
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- Hypertension Research
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Hypertension Research 24 (2), 89-92, 2001
The Japanese Society of Hypertension
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Details 詳細情報について
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- CRID
- 1390282679698132608
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- NII Article ID
- 130004436885
- 10008742161
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- NII Book ID
- AA10847079
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- COI
- 1:STN:280:DC%2BD3MvntlSqtw%3D%3D
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- ISSN
- 13484214
- 09169636
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- PubMed
- 11325079
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed