Lack of Association between Genetic Polymorphism of CYP11B2 and Hypertension in Japanese: The Suita Study.

• TSUJITA Yasuyuki

  Research Institute, National Cardiovascular Center First Department of Internal Medicine, Shiga University of Medical Science

• IWAI Naoharu

  Research Institute, National Cardiovascular Center Department of Hypertension and Nephrology, National Cardiovascular Center

• KATSUYA Tomohiro

  Department of Geriatric Medicine, Osaka University Medical School

• HIGAKI Jitsuo

  Department of Geriatric Medicine, Osaka University Medical School

• OGIHARA Toshio

  Department of Geriatric Medicine, Osaka University Medical School

• TAMAKI Shinji

  First Department of Internal Medicine, Shiga University of Medical Science

• KINOSHITA Masahiko

  First Department of Internal Medicine, Shiga University of Medical Science

• MANNAMI Toshifumi

  Department of Preventive Medicine, National Cardiovascular Center

• OGATA Jun

  Department of Preventive Medicine, National Cardiovascular Center

• BABA Shunroku

  Department of Preventive Medicine, National Cardiovascular Center

抄録

Aldosterone synthase (CYP11B2) is a key enzyme in the biosynthesis of aldosterone. Recently, a polymorphism in the 5'-flanking region of the CYP11B2 gene [T(−344)C] has been reported to be associated with blood pressure and plasma aldosterone levels. We investigated the association between this polymorphism and hypertension in a large population-based sample of 4,000 Japanese. The genotype distribution in hypertensive subjects (n=1,535) was compared to that in normotensive subjects (n=2,514). In subjects not receiving antihypertensive medication, the influence of the genotype on blood pressure values adjusted for clinical covariates was analyzed. All analyses were performed separately for men and women. The genotype distribution did not differ between hypertensive and normotensive subjects in either men (frequency of C allele: 30.3% vs. 31.4%, p=0.48) or women (31.5% vs. 31.7%, p=0.93). There were no significant differences in systolic blood pressure, diastolic blood pressure, or pulse pressure among the three genotypes in either men or women who had not received hypertensive medication. Our data suggest that the T(−344)C polymorphism of CYP11B2 is unlikely to influence blood pressure status in the Japanese population. (Hypertens Res 2001; 24: 105-109)

収録刊行物

• Hypertension Research

  Hypertension Research 24 (2), 105-109, 2001

  日本高血圧学会

キーワード

• aldosterone
• blood pressure
• cytochrome P-450 <I>CYP11B2</I>
• genetics
• hypertension

詳細情報

• CRID: 1390001204721426432
• NII論文ID: 130004436888
• NII論文ID: 10008742236
• NII書誌ID: AA10847079
• DOI: 10.1291/hypres.24.105
• COI: 1:CAS:528:DC%2BD3MXjtVOhsrc%3D
• ISSN: 13484214
• ISSN: 09169636
• PubMed: 11325068
• Web Site: https://search.jamas.or.jp/link/ui/2001172048
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可