Effect of Long-Acting Isosorbide-5-Mononitrate Administration on Large Artery Distensibility in Patients with Essential Hypertension.

DOI PubMed 被引用文献6件 参考文献43件
  • WANG Hongyu
    Department of Cardiology, People’s Hospital, Peking University
  • HU Dayi
    Department of Cardiology, People’s Hospital, Peking University
  • SUN Ningling
    Department of Cardiology, People’s Hospital, Peking University
  • GONG Lansheng
    Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Second Medical University
  • ZHANG Weizhong
    Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Second Medical University

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To evaluate the clinical efficacy of long-acting nitrates, isosorbide-5-mononitrate (IS-5-MN), on large artery distensibility in patients with essential hypertension. Large arterial distensibility was assessed by automatic noninvasive measurement of the carotid-femoral pulse wave velocity (PWV). Seventeen patients aged 62.53±7.94 years (mean±SD) with essential hypertension undering long-term antihypertensive therapy were studied in this trial. PWV was measured 2 weeks and 4 weeks after oral administration of IS-5-MN (30 mg once daily) with previous therapy. There was no significant difference in systolic blood pressure, diastolic blood pressure, pulse pressure or heart rate at 2 weeks and 4 weeks after treatment compared with baseline. The carotid-femoral PWV decreased significantly at 2 and 4 weeks after treatment (p<0.05, p<0.05, respectively). Long-acting nitrates have potential value in improving large arterial distensibility in patients with essential hypertension independent of blood pressure alteration. It might be used as an effectively additive drug in hypertension control. (Hypertens Res 2001; 24: 311-314)

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