Effect of Long-Acting Isosorbide-5-Mononitrate Administration on Large Artery Distensibility in Patients with Essential Hypertension.
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- WANG Hongyu
- Department of Cardiology, People’s Hospital, Peking University
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- HU Dayi
- Department of Cardiology, People’s Hospital, Peking University
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- SUN Ningling
- Department of Cardiology, People’s Hospital, Peking University
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- GONG Lansheng
- Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Second Medical University
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- ZHANG Weizhong
- Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Second Medical University
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To evaluate the clinical efficacy of long-acting nitrates, isosorbide-5-mononitrate (IS-5-MN), on large artery distensibility in patients with essential hypertension. Large arterial distensibility was assessed by automatic noninvasive measurement of the carotid-femoral pulse wave velocity (PWV). Seventeen patients aged 62.53±7.94 years (mean±SD) with essential hypertension undering long-term antihypertensive therapy were studied in this trial. PWV was measured 2 weeks and 4 weeks after oral administration of IS-5-MN (30 mg once daily) with previous therapy. There was no significant difference in systolic blood pressure, diastolic blood pressure, pulse pressure or heart rate at 2 weeks and 4 weeks after treatment compared with baseline. The carotid-femoral PWV decreased significantly at 2 and 4 weeks after treatment (p<0.05, p<0.05, respectively). Long-acting nitrates have potential value in improving large arterial distensibility in patients with essential hypertension independent of blood pressure alteration. It might be used as an effectively additive drug in hypertension control. (Hypertens Res 2001; 24: 311-314)
収録刊行物
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- Hypertension Research
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Hypertension Research 24 (3), 311-314, 2001
日本高血圧学会
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詳細情報
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- CRID
- 1390282679696089728
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- NII論文ID
- 10008743101
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- NII書誌ID
- AA10847079
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- COI
- 1:CAS:528:DC%2BD3MXkvVKku7o%3D
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- ISSN
- 13484214
- 09169636
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- PubMed
- 11409656
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可