子牛における長時間作用型アモキシシリンの血中動態ならびにパスツレラ性肺炎に対する治療効果  [in Japanese] Pharmacokinetics and Antibacterial Effects of Long-acting Amoxicillin on Calves Pneumonia Caused by Pasteurella  [in Japanese]

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Author(s)

Abstract

新しく開発された長時間作用型アモキシシリン (150mg/ml) を用い, 7.5, 15および30mg (力価)/kgの投与量でそれぞれ5頭の子牛に筋肉内注射した. 投与後経時的に採血し, 血L清中のアモキシシリン濃度を生物学的定量法により測定した. また野外より採取した<I>Pasteurella multocida</I> 10菌株の最小発育阻止濃度を測定した. さらに, 野外で自然発生したパスツレラ性肺炎子牛15頭を用い抗菌効果を調べた. 以上の結果, 本剤15または30mg/kgの48時間ごとの筋肉内投与は, パスツレラ性肺炎に有効であると考えられた.

The antimicrobial effects and pharmacokinetics of long-acting amoxicillin (150mg/ml) were investigated. Following intramuscular administration of the antibiotic (7.5, 15, or 30 mg/kg) to 15 calves, bioassays were conducted to determine serum antibiotic concentration. Minimum inhibitory concentrations for 10 strains of <I>Pasteurella multocida</I> obtained from domestic farms were measured. Clinical effects of the antibiotic on 15 calves with pneumonia caused by Pasteurella were investigated. Results show that intramuscular injections of 15mg/kg or 30mg/kg of amoxicillin every 48 hrs seem to be effective in treating calf pneumonia caused by Pasteurella.

Journal

  • Journal of the Japan Veterinary Medical Association

    Journal of the Japan Veterinary Medical Association 54(4), 255-259, 2001-04-20

    Japan Veterinary Medical Association

References:  17

Codes

  • NII Article ID (NAID)
    10008760552
  • NII NACSIS-CAT ID (NCID)
    AN00191857
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    04466454
  • NDL Article ID
    5754639
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-352
  • Data Source
    CJP  NDL  J-STAGE  JASI 
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