犬の全身吸入麻酔の麻酔前投薬-導入薬としてのメデトミジン-チオペンタール, メデトミジン-ケタミン, メデトミジン-プロポフォールの臨床的検討  [in Japanese] Medetomidine with Thiopental, Ketamine, or Propofol as Premedication and Induction for Inhalation Anesthesia in Dogs  [in Japanese]

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Abstract

犬150頭 (ASA分類Class IおよびII, 6.0±4.2歳) の麻酔前投薬と導入薬として, メデトミジン5μg/kgの前投薬後, 導入薬としてチオペンタール12.5mg/kg (MT群), ケタミン5mg/kg (MK群) またはプロポフォール4mg/kg (MP群, 各群50頭) を静脈内投与し, 50%笑気-50%酸素-セボフルラン麻酔を実施した. 導入時にMK群8頭に痙攣, MP群1頭に血管痛を認めた. 挿管後, MT群では高率に無呼吸となり, 32頭に調節呼吸を実施した. 術中の終末呼気セボフルラン濃度は, MT群1.6~1.7%, MK群1.9~2.0%, MP群2.1~2.3%であった. いずれも術中の心拍数は110回/分, 平均動脈血圧は100~120mmHg前後で推移し, 麻酔終了後5分前後で抜管することができた. これらの組み合わせは全身状態の良好な犬臨床例に有用と考える.

Combinations of medetomidine (5μg/kg IV) with thiopental (12.5 mg/kg IV; MT, n=50), ketamine (5 mg/kg IV; MK, n=50), or propofol (4mg/kg IV; MP, n=50) were evaluated as premedication and induction for inhalation anesthesia in 150 dogs (ASA Classes I and II, 6.0±4.2 years old). Surgical anesthesia was maintained with 50% nitrous oxide and 50% oxygen-sevoflurane. All dogs became calm and relaxed after administration of medetomidine. Heart rates decreased in 145 dogs (59.7±21.1% of preanesthetic values).Vomiting occurred in 29 dogs. One dog demonstrated signs of pain upon being injected with propofol. After administration of ketamine, convulsions occurred in 8 dogs. An initial period of apnea was observed after intubation in 42 MT, 15 MK, and 15 MP dogs. Controlled ventilation was required for 32 MT and 8 MK dogs. End-tidal sevoflurane concentration during surgery was 1.6-1.7% in MT, 1.9-2.0% in MK, and 2.1-2.3% in MP dogs. During all treatment, heart rate was maintained at approximately 110 bpm and mean arterial blood pressure at between 100 and 120 mmHg. Recovery was rapid and most dogs were extubated within 5 minutes after the end of anesthesia. MT, MK, and MP resulted in smooth induction and rapid recovery from anesthesia in dogs free of severe systemic diseases. Apnea was the most frequently observed side effect.

Journal

  • Journal of the Japan Veterinary Medical Association

    Journal of the Japan Veterinary Medical Association 54(4), 282-287, 2001-04-20

    Japan Veterinary Medical Association

References:  22

Cited by:  3

Codes

  • NII Article ID (NAID)
    10008760666
  • NII NACSIS-CAT ID (NCID)
    AN00191857
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    04466454
  • NDL Article ID
    5754848
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-352
  • Data Source
    CJP  CJPref  NDL  J-STAGE  JASI 
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