コンホメーション固定による人工機能核酸の合成  [in Japanese] Synthesis of Artificial Nucleic Acids Functionalized by Fixation of Conformation  [in Japanese]

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Author(s)

    • 関根 光雄 SEKINE Mitsuo
    • 東京工業大学大学院生命理工学研究科分子生命科学専攻 Department of Life Science, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology

Abstract

Recent studies of the synthesis of oligonucleotides incorporating conformationally locked nucleoside or nucleotide building blocks have been comprehensively reviewed in connection with the antisense stratagy as well as creaction of new functions of DNA/RNA. The synthesis, and conformational properties of a wide varaiety of nucleoside derivatives locked by introduction of three, four, and five membered-ring systems to the deoxyribose or ribose moiety have been described. The hybridization abilities of oligonucleotides incorporating these locked-nuucleosides are also discussed. In addition, this review deals with the synthesis and properties of conformationally fixed cyclouridylate derivatives bridged between the uracil and the 5'-phosphate of 5'-uridylic acids and their successful application to the construction of bent DNA and RNA.

Journal

  • Journal of Synthetic Organic Chemistry, Japan

    Journal of Synthetic Organic Chemistry, Japan 58(1), 2-13, 2000-01-01

    The Society of Synthetic Organic Chemistry, Japan

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Codes

  • NII Article ID (NAID)
    10008818571
  • NII NACSIS-CAT ID (NCID)
    AN0024521X
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    00379980
  • NDL Article ID
    4957639
  • NDL Source Classification
    ZP11(科学技術--化学・化学工業--有機化学・有機化学工業)
  • NDL Call No.
    Z17-256
  • Data Source
    CJP  NDL  J-STAGE 
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