スクアレン環化酵素の生物有機化字 : 有機合成プローブを用いた酵素活性中心構造の探索  [in Japanese] Design and Synthesis of Active Site Probes for Squalene Cyclizing Enzymes.  [in Japanese]

Access this Article

Search this Article

Author(s)

Abstract

Enzymatic cyclizations of squalene and oxidosqualene lead to various skeletal types of sterols and triterpenes. The cyclases for these reactions catalyze formation and stabilization of polycyclic carbocations and direct the enzyme-specific, templated formation of new carbon-carbon bonds in regio- and stereochemically defined manner. Studies of these enzymes are now progressing rapidly and promise to reveal the intimate three-dimensional structural details of the enzyme-catalyzed processes. The development of mechanism-based irreversible inhibitors, photoactivatable inhibitors, and numerous substrate analogs have helped to unravel the stepwise events occurring in the catalytic sites of these enzymes by covalent modification of specific amino acid residues.

Journal

  • Journal of Synthetic Organic Chemistry, Japan

    Journal of Synthetic Organic Chemistry, Japan 58(8), 745-755, 2000-08-01

    The Society of Synthetic Organic Chemistry, Japan

References:  79

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008821174
  • NII NACSIS-CAT ID (NCID)
    AN0024521X
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    00379980
  • NDL Article ID
    5431958
  • NDL Source Classification
    ZP11(科学技術--化学・化学工業--有機化学・有機化学工業)
  • NDL Call No.
    Z17-256
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
Page Top