コレシストキニン拮抗剤の探索研究  [in Japanese] Synthetic Studies on Cholecystokinin Receptor Antagonists  [in Japanese]

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Abstract

Cholecystokinin (CCK) is a major gastrointestinal hormone with an important role in regulating various target organs such as pancreas, gallbladder and gut. CCK is also one of the most widely distributed neuropeptides in the brain and is considered as a putative central nervous system transmitter. The CCK receptors are divided into two CCK-A and CCK-B sub-type receptors. We have researched these respective receptor antagonists in the 1, 4-benzodiazepine derivatives and succeeded in discoveries of a selective CCK-A receptor antagonist, FK 480, a selective CCK-B receptor antagonist, FR 175985, and a dual CCK-A and -B receptor antagonist, FR 208419.<BR>This manuscript describes the syntheses and the structure-activity relationships of these respective CCK receptor antagonists.

Journal

  • Journal of Synthetic Organic Chemistry, Japan

    Journal of Synthetic Organic Chemistry, Japan 58(8), 766-775, 2000-08-01

    The Society of Synthetic Organic Chemistry, Japan

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Codes

  • NII Article ID (NAID)
    10008821337
  • NII NACSIS-CAT ID (NCID)
    AN0024521X
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    00379980
  • NDL Article ID
    5431996
  • NDL Source Classification
    ZP11(科学技術--化学・化学工業--有機化学・有機化学工業)
  • NDL Call No.
    Z17-256
  • Data Source
    CJP  NDL  J-STAGE 
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