コレシストキニンきっ抗剤の探索研究

• 佐藤 良也

  藤沢薬品工業株式会社研究本部化学研究所

書誌事項

タイトル別名

• Synthetic Studies on Cholecystokinin Receptor Antagonists.
• コレシストキニン キッコウザイ ノ タンサク ケンキュウ

抄録

Cholecystokinin (CCK) is a major gastrointestinal hormone with an important role in regulating various target organs such as pancreas, gallbladder and gut. CCK is also one of the most widely distributed neuropeptides in the brain and is considered as a putative central nervous system transmitter. The CCK receptors are divided into two CCK-A and CCK-B sub-type receptors. We have researched these respective receptor antagonists in the 1, 4-benzodiazepine derivatives and succeeded in discoveries of a selective CCK-A receptor antagonist, FK 480, a selective CCK-B receptor antagonist, FR 175985, and a dual CCK-A and -B receptor antagonist, FR 208419.<BR>This manuscript describes the syntheses and the structure-activity relationships of these respective CCK receptor antagonists.

収録刊行物

• 有機合成化学協会誌

  有機合成化学協会誌 58 (8), 766-775, 2000

  公益社団法人 有機合成化学協会

キーワード

• cholecystokinin
• CCK
• CCK-A antagonist
• CCK-B antagonist
• dual CCK-A and -B antagonist
• structure-activity relationship
• FK 480
• FR 175985
• FR 208419

詳細情報

• CRID: 1390282680253855232
• NII論文ID: 10008821337
• NII書誌ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.58.766
• ISSN: 18836526
• ISSN: 00379980
• NDL書誌ID: 5431996
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5431996
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可