微生物由来生物活性天然物の効率的な全合成  [in Japanese] The Efficient Total Synthesis of Bioactive Microbial Natural Products  [in Japanese]

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Author(s)

    • 砂塚 敏明 SUNAZUKA Toshiaki
    • 北里大学薬学部,北里研究所 School of Pharmaceutical Science, Kitasato University, and Research Center for Biological Function, The Kitasato Institute

Abstract

We have been working on finding new bioactive microbial metabolites at the Kitasato Institute. Their microbial natural products have a variety of unique and complex skeletones with many chiral centers and functional groups, and biological activities. We also have been working on total synthesis of them, which is effective and concise convergent approach, designed to afford easy access to both the natural products and a variety of analogs to clarify the structure-activity relationships. We have succeeded the efficient total syntheses of bioactive microbial metabolites; pyripyropene A (1) and E, arisugacin (2), paspalicine (3) and paspalinine (4), lactacystin (5), macrosphelide (6), and madindoline (7). We also have succeeded to create better analogs of pyripyropene A (1) and lactacystin (5).

Journal

  • Journal of Synthetic Organic Chemistry, Japan

    Journal of Synthetic Organic Chemistry, Japan 58(9), 828-838, 2000-09-01

    The Society of Synthetic Organic Chemistry, Japan

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Codes

  • NII Article ID (NAID)
    10008821531
  • NII NACSIS-CAT ID (NCID)
    AN0024521X
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    00379980
  • NDL Article ID
    5474695
  • NDL Source Classification
    ZP11(科学技術--化学・化学工業--有機化学・有機化学工業)
  • NDL Call No.
    Z17-256
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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