コンビナトリアルケミストリー法およびダウンサイジング法による機能性核酸および機能性ペプチドの開発  [in Japanese] Development of Functional Nucleic Acids and Peptides by Combinatorial Chemistry and Downsizing Methods  [in Japanese]

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Author(s)

    • 杉本 直己 SUGIMOTO Naoki
    • 甲南大学理学部化学教室,ハイテクリサーチセンター Department of Chemistry, Faculty of Science and High Technology Research Center, Konan University

Abstract

Development of functional nucleic acids and peptides by combinatorial chemistry and downsizing methods is described. First, catalytic short RNAs (ribozymes) and DNAs (deoxyribozymes) are made and the metal ion effect on their activity is discussed. Surprisingly, these small nucleic acids can cleave RNA substrates at only one site precisely. Second, a novel and only 24 residue peptide derived from RecA protein can discriminate a single-stranded DNA (ssDNA) from a double-stranded DNA (dsDNA). A new developed support with this peptide recognizes ssDNA but not dsDNA. Finally, a novel screening method of combinatorial chemistry and its application for studying interactions between life molecules including sugars are reviewed.

Journal

  • Journal of Synthetic Organic Chemistry, Japan

    Journal of Synthetic Organic Chemistry, Japan 58(12), 1133-1143, 2000-12-01

    The Society of Synthetic Organic Chemistry, Japan

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Codes

  • NII Article ID (NAID)
    10008824335
  • NII NACSIS-CAT ID (NCID)
    AN0024521X
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    00379980
  • NDL Article ID
    5593914
  • NDL Source Classification
    ZP11(科学技術--化学・化学工業--有機化学・有機化学工業)
  • NDL Call No.
    Z17-256
  • Data Source
    CJP  NDL  J-STAGE 
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