モルモット海馬スライスにおけるカルバコール誘導リズム波の長期増強(LTP)に対する効果  [in Japanese] The Effects of Rhythmical Waves Induced by Carbachol on LTP in Guinea Pig Hippocampal Slices  [in Japanese]

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Author(s)

    • 夏目 季代久 NATSUME Kiyohisa
    • 九州工業大学情報工学部生物化学システム工学科 Department of Biochemical Engineering and Science, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology
    • 米谷 快男児 KOMETANI Kaoru
    • 九州工業大学情報工学部生物化学システム工学科 Department of Biochemical Engineering and Science, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology

Abstract

The cholinergic input to the hippocampus originates in the septum and diagonal band. A bath application of carbachol, a cholinergic agonist, induced different patterns of rhythmical waves depending on its concentration in guinea pig hippocampal slices. Tetanus-induced long-term potentiation (LTP) was differentially facilitated under several concentrations of carbachol. Under the concentrations, which were within the optimum range for generating theta-like waves, LTP was most facilitated. In addition, the higher augmentation of LTP occurred when LTP was induced during the generation of theta-like wave. These results suggested that depending on the activity of the cholinergic septal input to hippocampus, different patterns of rhythmical waves are induced and the plasticity in hippocampal neural networks can be modulated by them.

Journal

  • The Brain & Neural Networks

    The Brain & Neural Networks 3(4), 135-140, 1996-12-05

    Japanese Neural Network Society

References:  17

Codes

  • NII Article ID (NAID)
    10008841212
  • NII NACSIS-CAT ID (NCID)
    AA11658570
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    1340766X
  • Data Source
    CJP  J-STAGE 
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