強皮症と自己免疫

• 藤本 学

  国立国際医療センター研究所細胞組織再生医学研究部細胞修飾生体反応研究室

書誌事項

タイトル別名

• Scleroderma and Autoimmunity
• 生涯教育講座 強皮症と自己免疫
• ショウガイ キョウイク コウザ キョウ ヒショウ ト ジコ メンエキ

抄録

Scleroderma is an autoimmune disorder characterized by fibrosis in the skin and is divided into two types: systemic sclerosis and localized scleroderma. The etiology and pathogenesis of scleroderma are still unclear. Autoantibodies have been useful diagnostic tools and their clinical significance is reviewed in this article. Furthermore, recent studies have revived the idea that autoantibodies and B lymphocytes play principal roles in systemic autoimmune diseases. In the tight skin (Tsk/+) mouse, a genetic model of systemic sclerosis, B cells exhibit a hyper-responsive phenotype due to the disruption of the CD22/SHP-1 negative regulatory pathway. This inhibitory pathway is regulated by CD19, and the loss of CD19 expression significantly reduces skin fibrosis and autoantibody production in Tsk/+ mice. Two features of scleroderma, fibrosis and autoimmunity, thus affect each other, which may provide a clue to comprehending the pathogenesis of the disease.

収録刊行物

• 日本皮膚科学会雑誌

  日本皮膚科学会雑誌 112 (6), 785-792, 2002

  公益社団法人 日本皮膚科学会

キーワード

• scleroderma
• autoantibody
• B lymphocyte
• Tsk mouse

詳細情報

• CRID: 1390282680715312768
• NII論文ID: 10008880592
• NII書誌ID: AN00196602
• DOI: 10.14924/dermatol.112.785
• ISSN: 13468146
• ISSN: 0021499X
• NDL書誌ID: 025117272
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025117272
• Web Site: https://search.jamas.or.jp/link/ui/2002242182
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可