Sequence Effects on Helix-Sheet Conformational Transitions of Designed Amphiphilic Peptides

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抄録

Four 18-residue amphiphilic peptides were designed and synthesized, and their helix-sheet conformational transitions were investigated by circular dichroism (CD) in aqueous solution at different pH, peptide concentration and ionic strength as well as in a water/HFIP mixture. The <i>α</i>-helical conformations existed as monomeric states, while the <i>β</i>-sheet structures were formed by the aggregation of approximately 6 monomeric peptides for Peptide I, II, and III. The conformational transitions were provided by the self-association and dissociation of each peptide. The aggregated <i>β</i>-sheet structures would be stabilized by intermolecular hydrophobic interactions and complementary ionic bonds in addition to the conventional hydrogen bonds. In contrast, the formation of <i>α</i>-helical conformations would be caused by intramolecular electrostatic interactions between charged residues and the intrinsic high <i>α</i>-helix propensities of constituent amino acids in addition to hydrogen bonds. These peptides could be useful models for studying the factors governing the stability of secondary and tertiary structures as well as conformational transitions for comprehending the principles of how proteins fold into native states.

収録刊行物

  • Bulletin of the Chemical Society of Japan

    Bulletin of the Chemical Society of Japan 69(3), 701-708, 1996-03-15

    公益社団法人 日本化学会

参考文献:  25件中 1-25件 を表示

  • <no title>

    ANFINSEN C. B.

    Adv. Protein Chem. 29, 205, 1975

    被引用文献2件

  • <no title>

    HO S. P.

    J. Am. Chem. Soc. 109, 6751, 1987

    被引用文献3件

  • <no title>

    TANAKA T.

    J. Cell Biochem. 14, 233, 1990

    被引用文献2件

  • <no title>

    QUINN T. P.

    Proc. Natl. Acad. Sci. U. S. A. 91, 8747, 1994

    被引用文献1件

  • <no title>

    KIM P. S.

    Annu. Rev. Biochem. 59, 631, 1990

    被引用文献1件

  • <no title>

    FASMAN G. D.

    Poly-α-amino Acids, 1967

    被引用文献4件

  • <no title>

    KRIMM S.

    Adv. Protein Chem. 38, 181, 1986

    被引用文献11件

  • <no title>

    RIPPON W. B.

    J. Mol. Biol. 75, 369, 1973

    被引用文献4件

  • <no title>

    FUKUSHIMA Y.

    Polym. J. 27, 819, 1995

    被引用文献2件

  • <no title>

    CHOU P. Y.

    Adv. Enzymol. 47, 45, 1978

    被引用文献6件

  • <no title>

    BRACK A.

    Nature 256, 383, 1975

    被引用文献6件

  • <no title>

    TAKAKURA T.

    Anal. Sci. 1, 215, 1985

    被引用文献4件

  • <no title>

    LYU P. C.

    Proc. Natl. Acad. Sci. U.S.A. 88, 5371, 1991

    被引用文献2件

  • <no title>

    GREENFIELD N.

    Biochemistry 8, 4108, 1969

    被引用文献16件

  • <no title>

    MARQUSEE S.

    Proc.Natl.Acad.Sci.U.S.A. 84, 8898, 1987

    被引用文献3件

  • <no title>

    FINKELSTEIN A. V.

    J. Mol. Biol. 103, 15, 1976

    被引用文献1件

  • <no title>

    EPAND R. F.

    Biopolymers 6, 1383, 1968

    被引用文献5件

  • <no title>

    PARRISH J. R.

    Biopolymers 11, 1001, 1972

    被引用文献2件

  • <no title>

    CREIGHTON T. E.

    Biochem. J. 270, 1, 1990

    被引用文献8件

  • <no title>

    CREIGHTON T. E.

    Biochem. J. 270, 1, 1990

    被引用文献8件

  • <no title>

    LENORMANT H.

    J. Am. Chem. Soc. 80, 6191, 1958

    DOI 被引用文献5件

  • <no title>

    MUTTER M.

    Angew. Chem., Int. Ed. Engl. 29, 185, 1990

    被引用文献6件

  • <no title>

    MUTTER M.

    Angew. Chem. Int. Ed. 30, 1514-1516, 1991

    被引用文献7件

  • <no title>

    DADO G. P.

    J. Am. Chem. Soc. 115, 12609, 1993

    DOI 被引用文献2件

  • <no title>

    SEIPKE G.

    Biopolymers 13, 1621, 1974

    DOI 被引用文献4件

各種コード

  • NII論文ID(NAID)
    10008900680
  • NII書誌ID(NCID)
    AA00580132
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00092673
  • データ提供元
    CJP書誌  J-STAGE 
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