Palladium-Catalyzed Arylation of Azole Compounds with Aryl Halides in the Presence of Alkali Metal Carbonates and the Use of Copper Iodide in the Reaction.
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- Pivsa-Art Sommai
- Department of Applied Chemistry, Faculty of Engineering, Osaka University
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- Satoh Tetsuya
- Department of Applied Chemistry, Faculty of Engineering, Osaka University
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- Kawamura Yoshiki
- Department of Applied Chemistry, Faculty of Engineering, Osaka University
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- Miura Masahiro
- Department of Applied Chemistry, Faculty of Engineering, Osaka University
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- Nomura Masakatsu
- Department of Applied Chemistry, Faculty of Engineering, Osaka University
書誌事項
- タイトル別名
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- Palladium-Catalyzed Arylation of Azole
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The reactions of iodobenzene with azole compounds, 1,2-disubstituted imidazoles and 2-substituted oxazoles and thiazoles, were examined in the presence of catalytic amounts of Pd(OAc)2 and PPh3 in DMF using alkali metal carbonates as bases. It was found that the coupling products, 5-arylazoles, could be selectively produced in good yields by using Cs2CO3. In the case that their 2-position is unsubstituted, the site could also be arylated. In reactions using bromobenzene in place of iodobenzene, K2CO3 was also as effective as Cs2CO3. The addition of a stoichiometric amount of CuI appeared to specifically promote the reactions of thiazoles as well as those of thiophene derivatives. The reactions of 2-unsubstituted azole compounds with aryl iodides could be mediated by CuI to some extent without using the palladium species to give 2-arylazoles.
収録刊行物
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- Bulletin of the Chemical Society of Japan
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Bulletin of the Chemical Society of Japan 71 (2), 467-473, 1998
公益社団法人 日本化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204121377920
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- NII論文ID
- 130004149975
- 10008929007
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- NII書誌ID
- AA00580132
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- ISSN
- 13480634
- 00092673
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- NDL書誌ID
- 4406068
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可