Structure-Activity Relationship of Norzoanthamine Exhibiting Significant Inhibition of Osteoporosis

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Author(s)

Abstract

Norzoanthamine is a zoanthamine-type alkaloid from the colonial zoanthid <i>Zoanthus</i> sp. Norzoanthamine hydrochloride, which suppresses the decrease in bone weight and strength in ovariectomized mice, could be a good candidate for an osteoporotic drug. Although the relative configuration of norzoanthamine was established based on an X-ray crystallographic analysis, the absolute stereochemistry of norzoanthamine remains unclear. To investigate their biogenesis and mechanisms of biological action, we conducted chemical and spectroscopic studies to determine the absolute configuration of norzoanthamines.

Journal

  • Bulletin of the Chemical Society of Japan

    Bulletin of the Chemical Society of Japan 71(4), 771-779, 1998-04-15

    The Chemical Society of Japan

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Codes

  • NII Article ID (NAID)
    10008930281
  • NII NACSIS-CAT ID (NCID)
    AA00580132
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00092673
  • NDL Article ID
    4462517
  • NDL Source Classification
    ZP1(科学技術--化学・化学工業)
  • NDL Call No.
    Z53-B35
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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