Regulation of Energy Metabolism by Peculiar Processing of Glucagon in Intestines in Surgically Stressed Patients.

• Tanjoh Katsuhisa

  Department of Emergency and Critical Care Medicine, Nihon University Shool of Medicine

• Tomita Ryouichi

  First Department of Surgery, Nihon University Shool of Medicine

• Mera Koichi

  Department of Emergency and Critical Care Medicine, Nihon University Shool of Medicine

• Shirai Kunihiro

  Department of Emergency and Critical Care Medicine, Nihon University Shool of Medicine

• Hayashi Nariyuki

  Department of Emergency and Critical Care Medicine, Nihon University Shool of Medicine

Bibliographic Information

Other Title

• 外科侵襲患者における特異腸管グルカゴンプロセッシングによるエネルギー代謝動態の調節

Abstract

We studied the insulin: glucagon (I/G) molar ratio and kinetics of glucagon and glucagon-related peptides assessed by radioimmunoassay and gel filtration chromatography and assessed energy metabolic status using indirect calorimetry in 16 patients with acute abdominal disorders who underwent emergency surgery (group P). We discuss glucagon processes and the correlation of glucagon kinetics and energy metabolism in surgically stressed status. Ten healthy subjects were enrolled as controls (group C). After surgery, the I/G ratio significantly decreased compared to that of group C. In 11 of the 16 patients in group P, a peculiar glicentin-like peptide (GLLP: MW about 8000) other than pancreatic glucagon was seen in gel filtration chromatography, which was absolutely not seen in group C, and was presumed to have been generated from the glucagon precursor in the intestine in a quite different glucagon process. In results of indirect calorimetry, nonprotein respiratory quotients (RQ) in 11 patients in whom GLLP were seen in chromatography were significantly lower than those in 5 patients without GLLP. In conclusion, the kinetics and processing of glucagon in most surgically stressed patients was quite different from those of healthy subjects, which may greatly influence and regulate energy metabolism after surgery.

Journal

• Nihon Kyukyu Igakukai Zasshi

  Nihon Kyukyu Igakukai Zasshi 13 (4), 183-194, 2002

  Japanese Association for Acute Medicine

Keywords

• glucagon
• energy metabolism
• aggressive insult

Details

• CRID: 1390001204371172096
• NII Article ID: 130003625872
• NII Article ID: 10008941899
• NII Book ID: AN10284604
• DOI: 10.3893/jjaam.13.183
• ISSN: 18833772
• ISSN: 0915924X
• Web Site: https://search.jamas.or.jp/link/ui/2002242723
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed