Triiodothyronine T3 Ameliorates Proinflammatory Cytokines in Septic Rat Model.

• Negishi Masatoshi

  Department of Emergency and Critical Care Medicine Gunma University School of Medicine

• Yokoe Takao

  Department of Emergency and Critical Care Medicine Gunma University School of Medicine

• Iino Yuichi

  Department of Emergency and Critical Care Medicine Gunma University School of Medicine

Bibliographic Information

Other Title

• ラット腹膜炎敗血症モデルでのＴ３投与による炎症性サイトカインの変化

Abstract

Purpose: We clarified the effects of triiodothyronine on proinflammatory cytokines in a septic rat model. Materials and Methods: Sprague-Dawley rats weighing 320-420g underwent cecal ligation and puncture (CLP) to induce sepsis and were grouped randomly as (1) control group: CLP only, (2) L group: CLP/T₃ 3ng/hr, and (3) H group: CLP/T₃ 15ng/hr. T₃ was administered subcutaneously by osmotic pump. Blood samples were obtained 24 hours after laparotomy from abdominal aorta and IL-1β, TNF-α, IL-6, IL-8, and free T₃ were measured. Results and Discussion: Proinflammatory cytokine production was suppressed by T₃ administration especially in the L group. Free T₃ was also maintained within the normal range by T₃ administration. All animals survived in the L and H groups, whereas 3 died in the control group. We concluded that T₃ replacement offers a good outcome in a septic rat model because it suppresses proinflammatory cytokines.

Journal

• Nihon Kyukyu Igakukai Zasshi

  Nihon Kyukyu Igakukai Zasshi 13 (5), 246-251, 2002

  Japanese Association for Acute Medicine

Keywords

• sepsis
• triiodothyronine
• proinflammatory cytokine

Details

• CRID: 1390282679345782656
• NII Article ID: 130003625879
• NII Article ID: 10008942030
• NII Book ID: AN10284604
• DOI: 10.3893/jjaam.13.246
• ISSN: 18833772
• ISSN: 0915924X
• Web Site: https://search.jamas.or.jp/link/ui/2002254696
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed