Effects of Treadmill Exercise on Muscle Fibers in Mice with Steroid Myopathy.

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  • Okita Minoru
    Department of Physical Therapy, School of Allied Medical Sciences, Nagasaki University
  • Yoshimura Toshiro
    Department of Occupational Therapy, School of Allied Medical Sciences, Nagasaki University
  • Nakano Jiro
    Department of Health Science, Graduate School of Medical Science, Hiroshima University
  • Watabe Miwako
    Department of Physical Therapy, School of Allied Medical Sciences, Nagasaki University
  • Nagai Tomoko
    Department of Rehabilitation, Yamashita Neuro Surgical Clinic
  • Kato Katsutomo
    Department of Physical Therapy, School of Allied Medical Sciences, Nagasaki University
  • Eguchi Katsumi
    The First Department of Internal Medicine, Nagasaki University School of Medicine

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We studied the effect of treadmill exercise on muscle fibers in mice with experimental steroid myopathy. Frozen sections of the extensor digitorum longus (EDL) and soleus (SOL) muscles were stained with hematoxylin-eosin, and the muscle fiber diameters measured. In the EDL, muscle fiber diameters in the steroid groups decreased significantly compared with those in the control groups; moreover, muscle fiber diameters in the exercise groups increased significantly compared with those in the non-exercise groups, whereas the diameters in the SOL did not differ. We speculate that treadmill exercise may prevent corticosteroid-induced muscle fiber atrophy.

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