Detection of Transforming Growth Factor-β1 in Coxsackie B3 Virus-Induced Murine Myocarditis

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Author(s)

    • ISHIDO Satoshi
    • Second Department of Pathology, Kobe University School of Medicine
    • SAKAUE Morito
    • Second Department of Pathology, Kobe University School of Medicine
    • ASAKA Kazuyuki
    • Second Department of Pathology, Kobe University School of Medicine
    • MAEDA Sakan
    • Second Department of Pathology, Kobe University School of Medicine

Abstract

To clarify the role of TGF-β1 in myocardial healing process after virus-induced myocarditis, we have examined the time course of TGF-β1 expression and its localization in myocardial healing process after Coxsackie B3-induced murine myocarditis. TGF-β1 immunoreactivity increased in parallel with its mRNA level and reached a peak at 10 days after Coxsackie B3 virus inoculation. Immunohistochemically, TGF-β1 was localized at pre-necrotic area at an early phase (5 days); it increased and extended to the area around the necrotic foci when necrosis became manifest (10 days); it decreased when macrophages and fibroblasts migrated to the necrotic foci (15 days); and then it reached a normal level and localized a little in perivascular and calcified regions (30 days). To our knowledge, this is the first study which demonstrates that TGF-β1 mRNA increases in viral-induced myocarditis at acute inflammatory phase. This result suggests that TGF-β1 promotes the migration of macrophages and fibroblasts to necrotic foci and induces fibrosis.

Journal

  • ACTA HISTOCHEMICA ET CYTOCHEMICA

    ACTA HISTOCHEMICA ET CYTOCHEMICA 28(2), 137-142, 1995-04-01

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

References:  21

Codes

  • NII Article ID (NAID)
    10008976310
  • NII NACSIS-CAT ID (NCID)
    AA00508022
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00445991
  • Data Source
    CJP  J-STAGE 
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