Molecular identification of LOX-1 and analysis of its pathophysiological role.

• SAWAMURA Tatsuya

  Department of Bioscience, National Cardiovascular Center Research Institute

Bibliographic Information

Other Title

• レクチン様酸化ＬＤＬ受容体ＬＯＸ‐１の同定とその病態生理学的意義の解析
• 〔第16回日本薬理学会学術奨励賞〕受賞者講演 レクチン様酸化LDL受容体LOX-1の同定とその病態生理学的意義の解析
• ダイ16カイ ニホン ヤクリ ガッカイ ガクジュツ ショウレイショウ ジュショウシャ コウエン レクチン ヨウ サンカ LDL ジュヨウタイ LOX 1 ノ ドウテイ ト ソノ ビョウタイ セイリガクテキ イギ ノ カイセキ

Abstract

Recent progress in the study of atherosclerosis revealed that the proatherogenic property of LDL is attributable to oxidized LDL. Macrophages recruited to vascular wall phagocytose oxidized LDL and transformed into foam cells, which is a hallmark of atheroma. Endothelial cells also binds oxidized LDL and changes its phenotype to the status of “endothelial dysfunction.” We successfully cloned the endothelial receptor for oxidized LDL, designated LOX-1. LOX-1-mediated action of oxidized LDL induces the decrease in NO release and the increased expression of adhesion molecules, which are typical changes in endothelial dysfunction. The expression of LOX-1 is quite inducible. Proinflammatory cytokines, etc. induce the expression of LOX-1 in vitro; and proatherogenic conditions, e.g., hypertension, hyperlipidemia, and diabetes, induce the expression of LOX-1 in vivo. This manner of expression suggests the importance of LOX-1 in pathological settings. LOX-1 binds not only oxidized LDL, but also binds apoptotic cells and activated platelets through the interaction with anionic phospholipids. This property might bridge atherosclerosis and thrombosis. A novel system to detect LOX-1 ligand in plasma detected the increased level of LOX-1 ligand in hypercholesterolemic rabbits compared with normal ones. This system might be useful to predict the status of endothelial function and the risk of ischemic heart disease.<br>

Journal

• Folia Pharmacologica Japonica

  Folia Pharmacologica Japonica 119 (3), 145-154, 2002

  The Japanese Pharmacological Society

Keywords

• LOX-1
• oxidized LDL
• endothelial cells
• atherosclerosis

Details

• CRID: 1390282679247799296
• NII Article ID: 10008991602
• NII Book ID: AN00198335
• DOI: 10.1254/fpj.119.145
• COI: 1:STN:280:DC%2BD387otlOitw%3D%3D
• ISSN: 13478397
• ISSN: 00155691
• NDL BIB ID: 6087440
• PubMed: 11915516
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6087440
• Web Site: https://search.jamas.or.jp/link/ui/2002213037
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed