小青竜湯(TJ-19)の鼻アレルギー患者の鼻閉塞に対する効果

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  • Effect of Sho-seiryu-to (Xiao-qing-long-tang) on Nasal Obstruction in Patients with Perennial Nasal Allergy
  • ショウ セイリュウトウ TJ-19 ノ ビ アレルギー カンジャ ノ ビヘイソ

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The efficacy of Tsumura Sho-seiryu-to granules,3 g/day for 2 weeks, for the treatment of nasal obstruction was evaluated in 11 p atients (7 males and 4 f emales, aged 19-53 years with a me an age of 33.5 y ears) with perennial nasal a llergy symptoms. A 100 m m v isual analogue scale (VAS) was u sed for subjective measurement of nasal sensations of airflow, and acoustic rhinometry (AR) was used for objective measurement at one, two and three weeks after the start of medication. Parame tric and non-parametric statistical tests were used to evaluate the results and P< 0.05 was con sidered to be significant.<BR>1) The mean ± standard error (SE) of the VAS score was 47.8 ± 6.3 before medication,32.0 ± 5.9 at one week,30.7 ± 6.7 at two weeks and 34.7 ± 7.5 at three weeks. The Friedman test showed signif icant variance in the VAS score (P=0.0395).<BR>2) The mean ± SE of the right +left nasal cavity volume (NCV) was 12.08 ± 0.82 cm3 before medication,14.53 ± 0.79 cm3 at one week,14.37 ± 0.82 cm3 at two weeks and 13.77 ± 1.10 cm3 at three weeks. One-way repeated-mesaures ANOVA showed significant variance in the NCV (P=0.0049).<BR>In conclusion, VAS and AR studies showed that Sho-seiryu-to appears to be effective in reducing allergy-induced nasal obstruction.

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