有機合成化学の挑戦‐２１世紀に向けて　合成反応　有機合成と抗体触媒

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  • Challenge of Organic Synthesis-toward the 21st Century. Organic Synthesis and Catalytic Antibodies.
  • ユウキ ゴウセイ ト コウタイ ショクバイ

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One of the major goals of catalytic antibodies is to provide tailor-made catalysts for use in practical organic synthesis. Reflecting the increasing demand for enantio- and regioselective catalysts in organic synthesis, the scope of antibody catalysis now encompasses a broad array of synthetically important reactions such as highly enantio- and regioselective C-C bond formations and programmable control of disfavored reaction pathways. The advances in antibody catalysis have now reached the stage where it is actually applied to preparative scale synthesis of optically active compounds. In this review, we focus on how antibody catalysis is designed and adopted to organic synthesis and describe (1) the antibody-catalyzed Diels-Alder reactions and aldol condensations as examples of highly enantio- and regioselective C-C bond formations, (2) the control of reaction pathways and selectivities by antibodies, (3) the catalytic antibodies with broad substrate specificity, (4) the applications of antibody catalysis to preparative organic synthesis, and (5) the antibody catalysis in organic solvents and the antibody immobilization.

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