Development of New Synthetic Methods and Strategies for the Total Syntheses of Pumiliotoxin A Class Alkaloids.

• Kibayashi Chihiro

• Aoyagi Sakae

  School of Pharmacy, Tokyo University of Pharmacy & Life Science

Abstract

New strategies for the syntheses of the pumiliotoxin (PTX) A dendrobatid alkaloids have been developed which are based on palladium-catalyzed carbonylation, palladium-catalyzed cross-coupling reaction, and nickel-chromium-mediated cyclization. Application of these methodologies to the asymmetric total syntheses of (-) -PTX 209F, (-) - PTX 225F, (+) -PTX A, (+) -allo-PTX 267A, (+) -allo-PTX 339A, and (+) -homo-PTX 223G is described.

Journal

• Journal of Synthetic Organic Chemistry, Japan

  Journal of Synthetic Organic Chemistry, Japan 57 (11), 981-992, 1999

  The Society of Synthetic Organic Chemistry, Japan

Keywords

• Organic Chemistry

Details

• CRID: 1390282680255563904
• NII Article ID: 10009346081
• NII Book ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.57.981
• ISSN: 18836526
• ISSN: 00379980
• NDL BIB ID: 4893927
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4893927
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed