書誌事項
- タイトル別名
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- Functional analysis of NALT immunity.
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The nasal mucosa is the first site of contact with inhaled antigens for the induction of IgA response. A major aim of this study was to characterize Th1 and Th2 cytokine expression by mucosal T cells residing in nasal-associated lymphoid tissue (NALT) and analyze NALT immunity as IgA inductive sites at transcriptional and cellular levels. The application of single-cell RT-PCR for the analysis of Th1 (IFN-γ) and Th2 (IL-4 and IL-6) cytokine-specific mRNA revealed the presence of CD4+T cells with a Th0 profile. NALT CD4+T cells did not provide a helper function for the induction of antibody-forming cells including IgA isotype in B-cell cultures. However, intranasally-immunized mice showed an increase of memory T cells and germinal center formation in NALT, and selected Th2-type cytokine expressing CD4+T cells were induced in NALT, which possessed a helper function for B cells. These findings suggest that NALT is characterized as a Th0 environment which can become Th1 and/or Th2 phenotype and has the capacity to be an IgA inductive site for nasopharyngeal mucosal immunity.
収録刊行物
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- 口腔・咽頭科
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口腔・咽頭科 10 (2), 169-174, 1998
日本口腔・咽頭科学会
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詳細情報 詳細情報について
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- CRID
- 1390282679404356864
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- NII論文ID
- 130004160839
- 10009351415
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- NII書誌ID
- AN10235405
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- ISSN
- 18844316
- 09175105
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可